ONS/ONCC Chemotherapy Immunotherapy Certificate

Lesson 1: Foundations to Set the Stage correct answer
Focusing on Cellular Structure and Function correct answer
The Normal Cell Cycle correct answer-The cell cycle refers to the ordered seres of processes of DNA
replication and mitosis, or cell division
-Cell nucleus regulates these processes by gathering and processing complexes molecular information
Interphase and Mitotic Phase correct answerCell division produces two identical cells through these two
major phases
During interphase: correct answerCell grows and DNA is replicated through the following three steps:
1: First growth phase (G1 or first gap)
2: Synthesis phase (S phase)
3:Mitotic Phse (M phase)
First Growth Phase (G1 or first gap) correct answer-cells increase in size
-reproduce RNA
-“quality assurance” test that the cell will be ready to synthesis DNA

-Length of time is variable, can be from hours to days
Synthesis Phase (S phase) correct answer-DNA replicates
-Results in the formation of identical pairs of DNA (chromatids)
-which are attached a t the centromere
-lasts 2-10 hours
Mitotic Phase (M phase) correct answer-Replicated chromosomes are aligned, separated, and move into
2 new, identical daughter cells
-takes about 30-60 minutes
Major points of cell regulation are entry and exit from correct answer-G1 checkpoint
-S Phase
-G2 checkpoint
-M phase
Restriction Point correct answer-The transition from the resting phase into an actively dividing phase
(G0-G1) is a point where cellular transformation can occur
-During this time, cells pass through a transition phase known as a restriction point

-Extracellular growth factors trigger reentry into G1, and GF are required to send the cells past the
restriction point, or the point of no return
G0 Phase (resting phase) correct answer-After mitosis, cells may enter back into the G1 phase or go into
a resting phase, known as G0
-Most cells in the human body reside in G0
-Exceptions to this are those that are (Resting in G0 phase) correct answer-Exceptions to this are those
that are metabollically active, such as
-granulocytes
-and the epithelium of the GI tract
Cell Cycling Time correct answerAmount of time from mitosis to mitosis
Cell cycle video and image correct
answerhttp://highered.mheducation.com/sites/0072495855/student_view0/chapter2/
animation__how_the_cell_cycle_works.html
Check points in the Cell Cycle: Keeping it All Under Control correct answer-The cell cycle is carefully
controlled through a series of checkpoints
-Variation in duplication or distribution of chromosomes during cell division can alter the genetic
information passed on to daughter cells, leading to cellular dysfunction and disease, such as cancer
-These checkpoints monitor for DNA integrity and control progression through mitosis
Progression through the cell cycle is controlled through two proteins: correct answer1. cyclines (D, E, A,
B)

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