Exam 4: NUR 210/ NUR210 (Latest 2023/ 2024) Principles of Pharmacology Exam| Questions and Verified Answers| 100% Correct | Galen
Exam 4: NUR 210/ NUR210 (Latest 2023/
2024) Principles of Pharmacology Exam|
Questions and Verified Answers| 100%
Correct | Galen
Q: IV voriconazole (Vfend) should be avoided in pts w/ …
Answer:
IV voriconazole (Vfend) should be avoided in pts w/ RENAL FAILURE due to cyclodextrin
excipient accumulation + CNS TOXICITY.
Q: Adverse effects of voriconazole (Vfend)?
Answer:
Adverse effects of voriconazole (Vfend):
HEPATIC TOXICITY (dose-dependent)/
VISUAL SYMPTOMS.
Q: Which anti-fungal med is the only INDUCER of P450 enzyme?
Answer:
GRISEOFULVIN is the only INDUCER of P450 enzyme.
Q: Amphotericin B can only be given via …
Answer:
Amphotericin B can only be given via IV.
(poorly absorbed in GI tract)
Q: 3 major adverse effect groupings of amphotericin B?
Answer:
3 major adverse effect groupings of amphotericin B:
SYSTEMIC (cytokine storm)/
RENAL (ischemia; dose-related)/
HEMATOLOGICAL (anemia – dose-related).
Q: Amphotericin B poorly penetrates …
Answer:
Amphotericin B poorly penetrates CSF.
(also poorly absorbed in GI tract)
Q: Which drug acts by binding ergosterol & disrupting fungal membrane stability?
Answer:
AMPHOTERICIN acts by binding ergosterol & disrupting fungal membrane stability.
Q: Ketoconazole poorly penetrates …
Answer:
Ketoconazole poorly penetrates
CSF & URINE.
Q: Adverse effects of ketoconazole?
Answer:
Adverse effects of ketoconazole:
INHIBITS HEPATIC P450 ENZYMES/
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