A nurse is teaching a class about using niacin to reduce LDL cholesterol.
The nurse should include in the teaching that which of the following conditions is a contraindication for receiving this medication?
A.
Hyperthyroidism.
B.
Asthma.
C.
High blood pressure.
D.
Active liver disease.
The correct answer is D. Active liver disease.
Explanation:
Niacin (vitamin B3) is used to lower LDL cholesterol and triglycerides and increase HDL cholesterol. However, niacin can cause liver toxicity, especially at high doses. Because of this, it is contraindicated in individuals with active liver disease, as it can exacerbate liver dysfunction.
Let’s review the other options:
- A. Hyperthyroidism:
Niacin is not specifically contraindicated in patients with hyperthyroidism. Hyperthyroidism may need monitoring, but it is not a contraindication for niacin therapy. - B. Asthma:
While niacin can sometimes cause flushing or a sensation of warmth, which might exacerbate asthma symptoms, it is not a direct contraindication. However, patients with asthma should be monitored for any worsening of their symptoms. - C. High blood pressure:
Niacin can cause vasodilation and may sometimes result in a slight drop in blood pressure. High blood pressure is not a contraindication, although blood pressure should be monitored.
Given that niacin has a risk of causing or worsening liver damage, active liver disease is the most critical contraindication to its use. Therefore, the correct answer is D. Active liver disease.