Chemotherapy Immunotherapy Certificate in Question 6 of 60 Which of the following medications is a tyrosine kinase inhibitor? A. Lenalidomide B. Cetuximab C. Empagliflozin D. Erlotinib MacBook Air courses.ons.org ON Dashboard ONS ONCC Chemotherapy Chemotherapy Immunotherapy Certificate Initial … Question 11 of 60 Maintaining a treatment plan’s dose intensity is associated with: A. improved patient survival. B. dose reductions c. increased toxicity D. decreased tumor response. Flag for Review my Varanger my 11.00 W POE MacBook Air Q1014 X xyzHomework Assessment My Drive – Google Drive HSC 12 – Google Drive = Module 1 activity – Goog. dy Find dz if y = (x + 4) (22+5) dy de = (x^2+4)312x+5)48x/2x+ Preview TIP Enter your answer as an expression. Example: 3x^2+1.x/5. (a+b)c Be sure your variables match those in the question Get Help: Question 6. Points possible: 1 This is attempt 3 of 3 Score on last attempt: 0. Score in gradebook: 0 Find if y = 3z”(32 + 5). Preview die TIP Enter your answer as an expression. Example: 3×2+1, 5. (a+b)/ Be sure your variables match those in the question My Drive – Google Drive HSC 12 – Google Drive Module 1 activity – Goog… dy Find without using the quotient rule; rather, rewrite the function by using a negative exponent and then use the product rule and t rule to find the derivative. dy da = Preview TIP Enter your answer as an expression. Example: 3x^2+1,x/5, (a+b Be sure your variables match those in the question Get Help Question 8. Points possible: 1 This is attempt 3 of 3. Score on Inst attempt: 0. Score in gradebook: 0 dy Find da without using the quotient rule; rather, rewrite the function by using a negative exponent and then use the product rule and it rule to find the derivative. 5 (x + 4) dy dar = Preview TIP Enter your answer as an expression. Example: 3x^2+1, x/5, (a+b)/ de A population researcher has found that the population P (in thousands) of a city in a particular year is a function of the number N (in thousands) of the jobs available in that year which is, in turn, a function of the economy E (in billions of dollars) of the state in which that city is located. The researcher has determined that for a particular year, E = 207, dP dN dP dN = 9, and = 0.4. Find de At E = 207, the population increases by * thousand people for each billion dollar increase in the state’s economy. TIP Enter your answer as an integer or decimal number. Examples: 3,4,5,5172 Enter DNE for Does Not Exist, oo for Infinity Get Help: Question 11. Points possible: 1 This is attempt 3 of 3 Score on last attempt: 0. Score in gradebook: 0
The Correct Answer and Explanation is:
Question 6 of 60: Which of the following medications is a tyrosine kinase inhibitor (TKI)?
Answer: D. Erlotinib
Explanation
Tyrosine kinase inhibitors (TKIs) are a class of targeted cancer therapies that block specific enzymes known as tyrosine kinases, which are involved in the signaling pathways that regulate cell division, survival, and growth. In certain cancers, these enzymes become overactive or mutated, leading to uncontrolled cell proliferation. By inhibiting these enzymes, TKIs can effectively slow or stop the growth of cancer cells.
Erlotinib is a well-known example of a tyrosine kinase inhibitor. It specifically targets the epidermal growth factor receptor (EGFR), a transmembrane protein with intrinsic tyrosine kinase activity. EGFR is often overexpressed or mutated in non-small cell lung cancer (NSCLC) and some pancreatic cancers. Erlotinib works by binding to the ATP-binding site of EGFR, thereby blocking its activation and downstream signaling pathways that promote tumor cell growth and survival.:
- A. Lenalidomide: This is an immunomodulatory drug (IMiD) used in conditions such as multiple myeloma. It alters the immune response and affects the tumor microenvironment but is not a TKI.
- B. Cetuximab: This is a monoclonal antibody that also targets EGFR, but unlike erlotinib, it acts extracellularly by binding to the EGFR on the surface of cells and preventing activation by natural ligands. It is not a small-molecule tyrosine kinase inhibitor.
- C. Empagliflozin: This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor used in the treatment of type 2 diabetes mellitus. It is completely unrelated to tyrosine kinases or cancer therapy.
In conclusion, among the choices provided, Erlotinib is the correct and only example of a tyrosine kinase inhibitor, primarily used in targeted cancer therapy for specific tumors with EGFR mutations.
