The C1 inhibitor is noted because it:
promotes dissociation of the C1 complex. inhibits the classical and MBL pathways.
blocks formation of the C1 complex.
The first two answers are reasons why C1 inhibitor is noted.
All of the answers are reasons why C1 inhibitor is noted.
The correct answer and explanation is:
The correct answer is: All of the answers are reasons why C1 inhibitor is noted.
Explanation:
C1 inhibitor (C1-INH) plays a critical role in regulating the classical and lectin complement pathways, which are part of the immune system. The complement system helps defend against infections and clears damaged cells. It is made up of a cascade of proteins that are activated in response to pathogens or other triggers. C1-INH is important in maintaining balance within this system and preventing excessive or inappropriate activation.
- Promotes dissociation of the C1 complex: The C1 complex is the first step in the classical pathway of complement activation, composed of C1q, C1r, and C1s. C1-INH facilitates the dissociation of C1r and C1s from C1q, which is essential to stop the cascade from proceeding. By binding to C1r and C1s, it prevents further activation of downstream complement components.
- Inhibits the classical and MBL pathways: The classical pathway and the Mannose-binding lectin (MBL) pathway are two key ways the complement system can be activated. C1-INH inhibits the activation of these pathways by blocking the activity of C1r and C1s, thus preventing the amplification of the complement cascade. This inhibition is vital for controlling the complement response and preventing tissue damage or autoimmune reactions.
- Blocks formation of the C1 complex: By binding to C1r and C1s, C1-INH prevents the formation of the active C1 complex. This action is crucial for limiting the cascade of reactions that could otherwise result in excessive inflammation or damage to healthy tissues.
Thus, C1-INH serves as an essential regulatory molecule, ensuring that the complement system is activated only when necessary and does not cause harm through overactivation.