Cushing Syndrome is an increase in this hormone: – answer cortisol
why could cortisol be increased and causing Cushings? – answer 1. exogenous
corticosteroids, resulting in decreased ACHT and bilat adrenal atrophy
- primary adrenal adenoma hyperplasia or carcinoma, decreased ACTH and atrophy of
uninvolved adrenal gland - ACTH secreting pituitary adenoma, leading to increased ACTH; most common
Name pathological signs/symptoms of Cushing syndrome – answer 1. hypertension - weight gain
- moon facies
- abdominal striae
- truncal obesity
- buffalo hump
- osteoporosis
- hyperglycemia/insulin resis
- amenorrhea
- immunosuppression
How do you treat adrenal insufficiency? – answer glucocorticoid/mineralcorticoid
replacement
describe the differential diagnosis between primary adrenal insufficiency versus
secondary/tertiary adrenal insufficiency – answer primary: low cortisol, high ACTH
secondary/tertiary: low cortisol, low ACTH, due to pituitary disease, + response to ACTH
stimulation test
What is the name of primary adrenal insufficiency? – answer chronic condition –
Addisons Disease (JFK, increased MSH levels)
acute – occurs as a result of hemorrhage
Hyperaldosteronism features clinical presentation of the following symptoms: – answer
hypertension
decreased or normal K+
metabolic alkalosis
there is no edema due to aldosterone escape mechanism
what is the aldosterone escape mechanism? – answer aldosterone escape: