ONS Chemotherapy Immunotherapy Certificate Exam (2023/ 2024 Update) Questions and Verified Answers|100% Correct- Grade A
ONS Chemotherapy Immunotherapy
Certificate Exam (2023/ 2024 Update)
Questions and Verified Answers|100%
Correct- Grade A
Q: How is relative dose intensity (RDI) calculated?
Answer:
By comparing the dose that the patient ACTUALLY received to the planned dose of the standard
regimen
Q: How do alkylating agents work?
Answer:
By causing a break in the DNA helix strand, interfering with DNA replication and causing cell
death
Q: 3 subcategories of alkylating agents:
Answer:
- Nitrogen mustards
- Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they
work similarly) - Nitrosoureas
Q: Most common subcategory of alkylating agents:
Answer:
Nitrogen mustards
Q: Common alkylating agents:
Answer:
Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Q: Common platinum-based agents:
Answer:
Cisplatin (Platinol)
Carboplatin (Paraplatin)
Q: What is unique about nitrosoureas agents?
Answer:
Able to cross the blood-brain barrier; can be effective in treating some brain tumors
Q: Common nitrosoureas agents:
Answer:
Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Q: Hypersensitivity can occur with late doses of:
Answer:
Carboplatin
Q: These agents are typically categorized as highly emetogenic:
Answer:
- Alkylating agents
- Nitrosoureas
Q: Pre-administration labs for alkylating agents and nitrosoureas:
Answer:
BUN
Creatinine
CBC w/ diff
Q: What is the medication Mesna used for?
Answer:
Bladder protectant with administration of cyclophosphamide or ifosfamide
Q: Instruct pts receiving __ to avoid exposure to cold air and consuming cold fluids for
3-4 days following treatment
Answer:
Oxaliplatin
Q: How do antimetabolites function?
Answer:
By blocking DNA and RNA growth by interfering with enzymes needed for normal cell
metabolism
Q: Antimetabolites work in the _ phase.
Answer:
S
Q: What types of cells are best affected by antimetabolites?
Answer:
Cells with high division rates
Q: Common side effects of antimetabolites:
Answer:
Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Q: Common antimetabolite drugs:
Answer:
Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
Q: The institute for Safe Medication Practices recommends what route of administration for
vincristine?
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