1. Consider the structure of Viagra® (below). (20 pts. total) HN LORD viagra Lambenou solls obubond boqmo 1o ano se lo di shunaqa route com o ingia hwm stungura de las A How many sp2 hybridized atoms are there in this molecule? B. How many sp carbons are there in this molecule? C. What is the chemical formula of Viagra? D. How many lone pairs of electrons are in Viagra? E. In the table below, name the functional groups found in Viagra. Identify them in the structure using squares, circles, triangles, diamonds, etc. (The number of rows is not necessarily the number of functional groups!) Functional Group Identifying Shape Used a. b. c. d. e. f. alebo bezbog bra bb h.
The correct answer and explanation is:
To answer your questions about Viagra®, I will break down the problem and provide explanations for each part. Since I don’t have the chemical structure of Viagra® in front of me, I’ll use general knowledge of the compound to guide the answers. Viagra® (sildenafil citrate) has a known structure, so the following analysis applies:
A. How many sp² hybridized atoms are there in this molecule?
Explanation:
- sp² hybridized atoms are typically found in double bonds (C=C or C=O) or atoms in aromatic rings like benzene.
- In sildenafil, there are multiple sp² carbons in its benzene rings, the pyrimidine ring, and other parts of the molecule. Nitrogen and oxygen atoms in double-bonded or planar configurations also contribute to sp² hybridization.
Answer: Based on the structure, sildenafil has around 15-20 sp² atoms, depending on how you count the planar atoms in its rings.
B. How many sp carbons are there in this molecule?
Explanation:
- sp carbons are involved in triple bonds or are part of groups like –C≡N (nitrile). Sildenafil does not have triple bonds or sp carbons.
Answer: 0 sp carbons.
C. What is the chemical formula of Viagra®?
Explanation:
- Sildenafil citrate’s chemical formula is C22H30N6O4S (as sildenafil base) or C28H38N6O11S (as the citrate salt).
Answer: C22H30N6O4S (base form).
D. How many lone pairs of electrons are in Viagra?
Explanation:
- Lone pairs are found on heteroatoms (N, O, and S in sildenafil).
- Oxygen atoms have 2 lone pairs each, sulfur has 2 lone pairs, and nitrogen has 1 lone pair (except for those in planar sp² aromatic configurations).
Answer: Approximately 14-16 lone pairs, based on the structure.
E. Functional Groups Found in Viagra
Explanation: Sildenafil contains several functional groups:
- Aromatic Rings: Benzene and pyrimidine rings.
- Amine Group: Secondary and tertiary amines (-NH or -N).
- Sulfonamide Group: (-SO₂NH-).
- Ketone Group: Found in cyclic amides or carbonyl groups.
- Ether Group: A -C-O-C- bond.
Functional Group Table:
| Functional Group | Identifying Shape |
|---|---|
| Aromatic ring | Circle |
| Amine group | Square |
| Sulfonamide group | Triangle |
| Ketone group | Diamond |
| Ether group | Star |
Summary :
Sildenafil (Viagra®) is a complex molecule with multiple hybridized atoms, lone pairs, and functional groups that contribute to its pharmacological properties. Its sp² hybridized atoms are mainly found in the aromatic rings and double-bonded groups, amounting to around 15-20. It contains no sp carbons since there are no triple bonds. The chemical formula of sildenafil base is C22H30N6O4S, highlighting its heteroatom-rich structure. Lone pairs, predominantly on oxygen, nitrogen, and sulfur atoms, total approximately 14-16.
Key functional groups include aromatic rings (benzene and pyrimidine), amine groups (secondary and tertiary), a sulfonamide group (-SO₂NH-), a ketone group (carbonyl functionality), and an ether group. These groups play essential roles in the molecule’s biological activity by interacting with PDE-5 enzymes, leading to vasodilation effects that treat erectile dysfunction. Identifying these functional groups and understanding their electronic and spatial configurations explain sildenafil’s pharmacodynamics.
Would you like further clarifications or a drawing of the structure with labeled functional groups?