atch each stage of folliculogenesis to its description. 1 Secondary follicle 2 Primordial follicle 3 Primary follicle 4 Tertiary follicle 5 Mature follicle Match ea
The Correct Answer and Explanation is:
Correct Matching of Each Stage of Folliculogenesis to Its Description:
- Secondary follicle – Formation of multiple layers of granulosa cells and beginning of the formation of the theca layer.
- Primordial follicle – A primary oocyte surrounded by a single layer of flat squamous granulosa cells; the earliest and most immature stage.
- Primary follicle – Granulosa cells become cuboidal and proliferate; zona pellucida starts forming around the oocyte.
- Tertiary follicle – Also called an antral follicle; characterized by the formation of a fluid-filled cavity called the antrum.
- Mature follicle – Also known as the Graafian follicle; has a large antrum and is ready for ovulation.
Explanation
Folliculogenesis is the process by which ovarian follicles mature from their earliest form to the stage of ovulation. It begins with a primordial follicle, the most basic form, containing a primary oocyte surrounded by a single layer of flattened granulosa cells. These follicles exist in large numbers from birth and remain dormant until recruited for development.
Upon activation, a primordial follicle becomes a primary follicle. In this stage, granulosa cells become cuboidal and begin to proliferate. The zona pellucida, a glycoprotein layer surrounding the oocyte, also starts forming, marking a key structural change.
The next stage is the secondary follicle, where the granulosa cells multiply further to form multiple layers. The theca layer also begins to form outside the granulosa cells, eventually differentiating into the theca interna and theca externa, both of which contribute to hormone production, especially estrogen precursors.
Following this, the follicle develops into a tertiary follicle, also known as an antral follicle, distinguished by the appearance of the antrum—a fluid-filled space within the granulosa cell layers. This stage is significant for rapid follicular growth and increased hormone production.
Finally, the follicle reaches the mature (Graafian) stage, which features a large, well-defined antrum, a fully developed theca and granulosa structure, and an oocyte poised for ovulation. Only one follicle usually reaches this stage in a typical menstrual cycle.
Each stage of folliculogenesis is tightly regulated by hormonal cues (mainly FSH and LH) and is essential for successful reproduction. Understanding this process is crucial for studies in fertility, reproductive health, and endocrinology.
