MATCHING 6-3: HEMOSTATIC RESPONSE AND ACTION Match the hemostatic response with the correct action. Choices may be used more than once. Hemostatic Response Action A. Vasoconstriction 1. _ Amplification B. Platelet plug formation 2. Blood vessel contraction C. Hemostatic plug formation 3. Cross-linkage of fibrin D. Fibrinolysis 4. Initiation 5. Fibrin degradation 6. Platelet adhesion 7. Propagation 8. Soluble fibrin generation 9. Thrombin burst 10. _ Tissue factor activation
The Correct Answer and Explanation is:
Here are the correct matches between the hemostatic response and the appropriate action:
MATCHING 6-3: Hemostatic Response and Action
| Hemostatic Response | Action |
|---|---|
| A. Vasoconstriction | 2. Blood vessel contraction |
| B. Platelet plug formation | 6. Platelet adhesion |
| 1. Amplification | |
| 7. Propagation | |
| 9. Thrombin burst | |
| C. Hemostatic plug formation | 3. Cross-linkage of fibrin |
| 8. Soluble fibrin generation | |
| 10. Tissue factor activation | |
| 4. Initiation | |
| D. Fibrinolysis | 5. Fibrin degradation |
Explanation
Hemostasis is the body’s natural response to blood vessel injury, involving a complex interplay between vascular, platelet, and plasma factors to prevent excessive bleeding while maintaining blood flow. It consists of four major phases: vasoconstriction, platelet plug formation, coagulation (hemostatic plug formation), and fibrinolysis.
A. Vasoconstriction is the initial response to vascular injury, where smooth muscles in the blood vessel wall contract to reduce blood flow, represented by action 2 (blood vessel contraction).
B. Platelet plug formation involves several key actions. It begins with 6 (platelet adhesion), where platelets adhere to the exposed collagen at the injury site. This triggers 1 (amplification), where more platelets are activated, and 7 (propagation) of platelet activation. A 9 (thrombin burst) helps stabilize the platelet plug and enhances coagulation.
C. Hemostatic plug formation (also known as coagulation) follows the platelet plug phase and involves the transformation of fibrinogen to fibrin. This includes 4 (initiation) through 10 (tissue factor activation), which starts the coagulation cascade. 8 (soluble fibrin generation) and 3 (cross-linkage of fibrin) result in the formation of a stable, insoluble fibrin mesh that reinforces the platelet plug.
D. Fibrinolysis is the final phase of hemostasis. Once the vessel is healed, the clot must be removed. This process involves 5 (fibrin degradation), where plasmin breaks down the fibrin mesh, restoring normal blood flow.
Each phase of hemostasis is tightly regulated to ensure rapid and localized clot formation and eventual removal of the clot once repair is complete, preserving vascular integrity and preventing thrombosis.
