Immature thrombocytic cell characterized by a large nucleus HINT: This word includes a prefix as well as a combining form and suffix. Prefixes: hypo- mega- pro- Combining Forms: agglutin/o aggreg/o apher/o chrom/o cyt/o erythr/o hemat/o kary/o path/o plasm/o thromb/o Suffixes: -ation -ation -blast -esis -gen -ic -in -penia -poiesis -poietin Does anyone know what the final word would be that fits the definition?
The Correct Answer and Explanation is:
Correct Answer: Megakaryoblast
Explanation (300 words):
The term “megakaryoblast” fits the definition: an immature thrombocytic cell characterized by a large nucleus. This word is constructed using a prefix, combining form, and a suffix, following standard medical terminology rules.
- Prefix: “mega-“
The prefix “mega-” means large or great in size. This suits the definition well, since the cell in question contains a notably large nucleus, which is a distinguishing feature of this type of immature cell. - Combining form: “kary/o”
The combining form “kary/o” refers to the nucleus of a cell. It directly points to the structural focus of the cell described—its large nucleus. - Suffix: “-blast”
The suffix “-blast” is used in biology and medicine to denote an immature or precursor cell. These cells are typically involved in forming more specialized or mature cells. In this case, a “megakaryoblast” is the precursor of a megakaryocyte, which in turn gives rise to platelets (thrombocytes).
Putting these components together:
- “Mega” (large) + “kary/o” (nucleus) + “blast” (immature cell) = megakaryoblast
A megakaryoblast is an early developmental stage of cells in the bone marrow responsible for producing platelets, which are critical for blood clotting. These cells are characterized by their relatively large size and a prominent, lobulated nucleus, which makes them identifiable under microscopic examination during hematological analysis.
In the context of hematopoiesis (blood cell formation), the megakaryoblast develops into a megakaryocyte, which eventually fragments to release platelets into the bloodstream. The presence and activity of megakaryoblasts are especially relevant in disorders of blood clotting or platelet production, such as certain leukemias or bone marrow diseases.
