During a recent synthesis of hispidospermidin
During a recent synthesis of hispidospermidin, a fungal isolate and an inhibitor of phospholipase C, the investigators employed a novel, aliphatic Friedel-Crafts acylation (J. Am. Chem. Soc. 1998, 120, 4039–4040). The following acid chloride was treated with a Lewis acid, affording two products in a 3 : 2 ratio. Draw the mechanism for the formation […]
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