{"id":131020,"date":"2023-12-29T17:40:53","date_gmt":"2023-12-29T17:40:53","guid":{"rendered":"https:\/\/learnexams.com\/blog\/?p=131020"},"modified":"2023-12-29T17:40:56","modified_gmt":"2023-12-29T17:40:56","slug":"nr507-nr-507-week-8-exam-q-a-latest-2024-2025-advanced-pathophysiology-chamberlain","status":"publish","type":"post","link":"https:\/\/www.learnexams.com\/blog\/2023\/12\/29\/nr507-nr-507-week-8-exam-q-a-latest-2024-2025-advanced-pathophysiology-chamberlain\/","title":{"rendered":"NR507 \/ NR 507 Week 8 Exam Q &amp; A (Latest 2024 \/ 2025): Advanced Pathophysiology &#8211; Chamberlain"},"content":{"rendered":"\n<p>NR507 \/ NR 507 Week 8 Exam Q &amp; A (Latest 2024 \/ 2025): Advanced Pathophysiology &#8211; Chamberlain<\/p>\n\n\n\n<p>NR-507 Advanced Pathophysiology<br>Week 8 Exam Q &amp; A<br>trigeminal neuralgia<br>Correct Answer:<br>inflammation of the fifth cranial nerve characterized by sudden, intense,<br>brief attacks of sharp pain on one side of the face.<br>The trigeminal nerve is the fifth cranial nerve. It originates from the brain<br>and branches into the ophthalmic branch,maxillary branch, and mandibular<br>branch<br>Treatment of trigeminal neuralgia involves the use of anticonvulsant<br>medication.<br>a. True<br>b. False<br>Correct Answer:<br>True<br>Bell&#8217;s palsy involves an upper motor neuron lesion (False)-<br>a. True<br>b. False<br>Correct Answer:<br>Bell&#8217;s palsy involves a lower motor neuron lesion.<\/p>\n\n\n\n<p>Which of the following are characteristic of trigeminal nerve pain?<br>a. Often attacks suddenly and is intermittent<br>b. Pain can be incapacitating<br>c. Pain is described as sharp and stabbing<br>d. All of the above<br>Correct Answer:<br>all<br>Which of the following organisms are the most common causes of bacterial<br>meningitis in newborns?<br>a. Streptococci pneumoniae<br>b. Group B streptococci<br>c. Cryptococcus<br>d. Varicella zoster<br>Correct Answer:<br>Group B streptococci are the most common bacteria causing bacterial<br>meningitis in newborn.<br>The ability for the bacteria that causes meningitis to exit the primary<br>infection site to enter the meninges is based on the organism&#8217;s virulent<br>factors which include:<br>a. Colonization<br>b. Immune Evasion<br>c. Meningeal invasion<br>d. All of the above<br>Correct Answer:<br>All affect the virulence of the bacteria.<\/p>\n\n\n\n<p>The cells responsible for producing cerebrospinal fluid (CSF) in the ventricle<br>cavity are:<br>a. Ependymal cells<br>b. Synaptic cells<br>c. Glial cells<br>d. Nerve cells<br>Correct Answer:<br>The epidymal cells are responsible for producing CSF.<br>The basement membrane of the blood-brain barrier is surrounded by<br>astrocytes (glial cells).<br>a. True<br>b. False<br>Correct Answer:<br>This statement is true. The basement membrane of the blood-brain barrier is<br>surrounded by astrocytes (glial cells).<br>Meningitis<br>Correct Answer:<br>Meningitis is inflammation of the meninges. The meninges are the layers<br>that surround and protect the brain. It can be caused by either a bacteria,<br>virus or fungus<\/p>\n\n\n\n<p>Bacterial Meningitis<br>Correct Answer:<br>Newborns: Group B streptococci; E. Coli; Listeria Monocytogenes<br>Children and Teens: Neisseria Meningitidis; Streptococcus Pneumoniae<br>Streptococcus Pneumoniae; Listeria Monocytogenes<br>viral meningitis<br>Correct Answer:<br>More common:Enteroviruses, Herpes simplex, HIV<br>Less common: Mumps, varicella zoster, lymphocytic choriomeningitis<br>Fungal meningitis<br>Correct Answer:<br>Affects immunocompromised:<br>Cryptococcus<br>Coccidioides genuses<br>Tubercular Meningitis: Mycobacterium tuberculosis<br>Parasitic Meningitis:P. Falciparum<br>Powered by <a href=\"https:\/\/learnexams.com\/search\/study?query=\" target=\"_blank\" rel=\"noopener\">https:\/\/learnexams.com\/search\/study?query=<\/a><\/p>\n\n\n\n<p><a><strong>Post-Ictal Phase<\/strong><\/a><\/p>\n\n\n\n<p><a>Post-ictal phase of a seizure is characterized by confusion, unresponsiveness and muscle flaccidity.<\/a><\/p>\n\n\n\n<p><a>True<\/a><\/p>\n\n\n\n<p><a>False<\/a><\/p>\n\n\n\n<p><a>This statement is true. Post-ictal phase of a seizure is characterized by confusion, unresponsiveness and muscle flaccidity.<\/a><\/p>\n\n\n\n<p><a><strong>Etiology of Seizures<\/strong><\/a><\/p>\n\n\n\n<p><a>Which of the following is an etiology of a seizure?<\/a><\/p>\n\n\n\n<p><a>Meningitis.<\/a><\/p>\n\n\n\n<p><a>Psychiatric disorders.<\/a><\/p>\n\n\n\n<p><a>Cerebral bleeding.<\/a><\/p>\n\n\n\n<p><a>All of the above.<\/a><\/p>\n\n\n\n<p><a>All of the above<\/a><\/p>\n\n\n\n<p><a><strong>Focal Seizure<\/strong><\/a><\/p>\n\n\n\n<p><a>Which of the following is a characteristic of a focal seizure?<\/a><\/p>\n\n\n\n<p><a>Can involve both brain hemispheres.<\/a><\/p>\n\n\n\n<p><a>Usually involves one brain hemisphere.<\/a><\/p>\n\n\n\n<p><a>The symptoms are generalized.<\/a><\/p>\n\n\n\n<p><a>Patient will have both motor and sensory symptoms at the same time.<\/a><\/p>\n\n\n\n<p><a>A focal seizure only involves on brain hemisphere.<\/a><\/p>\n\n\n\n<p><a>A focal seizure only involves on brain hemisphere.<\/a><\/p>\n\n\n\n<p><a>This statement is true. Febrile seizures are most common in children ages 6 months to 5 years.<\/a><\/p>\n\n\n\n<p><a><strong>Seizure Development<\/strong><\/a><\/p>\n\n\n\n<p><a>Which of the following electrolyte abnormality is involved in the initiation and propagation phase of seizure development?<\/a><\/p>\n\n\n\n<p><a>Hyponatremia.<\/a><\/p>\n\n\n\n<p><a>Hypokalemia.<\/a><\/p>\n\n\n\n<p><a>Hypercalcemia.<\/a><\/p>\n\n\n\n<p><a>Hypernatremia.<\/a><\/p>\n\n\n\n<p><a>The initiation and propagation phase of seizure development is impacted by hyponatremia.<\/a><\/p>\n\n\n\n<p><a>Epilepsy vs Seizure<\/a><\/p>\n\n\n\n<p><strong>Convulsions<\/strong><\/p>\n\n\n\n<p>Epilepsy is a disorder that is due to one or more chronic conditions in the body. It is characterized by disturbed nerve cell activity in the brain. This leads to recurrent seizures. Seizures may occur due to brain trauma that leads to disturbed and uncontrolled nerve activity in the brain. It is important to differentiate between epilepsy and seizure.<\/p>\n\n\n\n<p>Seizure is a condition that occurs due to excessive and uncontrolled neuronal activity in the brain. The uncontrolled neuron activity can be generalized or localized to one area of the brain. For example, it can be localized just to the area that perceives the touch sensation. Whether it is generalized or localized, the excessive neuronal activity lead to the seizure. The type of seizure will depend on the area of the brain affected.<\/p>\n\n\n\n<p><a><strong>Mechanisms of Seizure Development<\/strong><\/a><\/p>\n\n\n\n<p>Normally there exists a balance between the excitation and inhibition of neurons in the CNS. Neuronal activity is regulated by acetylcholine (ACH) and gamma-Aminobutyric acid (GABA). Neurons are synchronously active at the same time when they are not supposed to be. The term active denotes neuron firing where they are sending electrical signals from neuron to neuron. A microscope view of a neuron will demonstrate that each electrical signal that passes through it are just ions floating in and out through protein channels (see diagram below). The ion flow is controlled through neurotransmitters. Neurotransmitters bind to the receptors to tell the cell to either open the ion channels to relay the chemical message (excitatory neurotransmitters) or close the ion channels to inhibit the electrical message (inhibitory neurotransmitters).<\/p>\n\n\n\n<p><a>Phases of seizures<\/a><\/p>\n\n\n\n<p>Phases of Seizures<br>During a seizure, clusters of neurons in the brain become temporarily impaired. Seizures develop in a group of neurons when there is hyperexcitability and usually happens in two phases:<br>Initiation phase: Some neurons become hyperexcited and start to have excess neuron discharges. One of the most important reasons relates to the body&#8217;s sodium level as in the case of hyponatremia.<br>Propagation phase: Normally the neurons that have neuronal discharges are surround by a zone of inhibitory neurons called the zone of hyperpolarization. This zone prevents the spread of excessive neuron discharges to other parts of the brain. But due to some abnormality in the brain, as in the case of decreased sodium levels, the zone of hyperpolarization gets depolarized that allows the spread of neurons to other parts of the brain.<br>In the diagram below, the electrical activity in the normal brain is displayed. Seizures can be partial or generalized in terms of the extent of the neuronal discharges. In a partial seizure, a portion of the brain is involved. During a generalized seizure, the neuronal discharge encompasses the entire cerebral cortex.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=100,onerror=redirect,w=120\/https:\/\/o.quizlet.com\/XnU2jQaGahqNW0jwvevSTQ.png\" alt=\"Image: Phases of seizures\"\/><\/figure>\n\n\n\n<p><a>Seizure Etiology<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=100,onerror=redirect,w=120\/https:\/\/o.quizlet.com\/C17yDRkirx-imrXkdkRX1A.png\" alt=\"Image: Seizure Etiology\"\/><\/figure>\n\n\n\n<p><a>This seizure is most common in children. It is caused by a genetic abnormality. They are characterized by sudden and brief loss of consciousness without muscle tone and last for only a few seconds. There is no associated post-ictal confusion.<\/a><\/p>\n\n\n\n<p><a>Absent Seizures<\/a><\/p>\n\n\n\n<p><a>This seizure is characterized by unconsciousness and muscle rigidity.<\/a><\/p>\n\n\n\n<p><a>Tonic Seizures<\/a><\/p>\n\n\n\n<p><a>There is wide-spread and uncontrolled neuron activity in the entire cerebral cortex. These occur in 10% of patients who have epilepsy. There is excessive neuronal discharge in the motor nerves through the brain.<\/a><\/p>\n\n\n\n<p><a>Generalized tonic-clonic seizures:<\/a><\/p>\n\n\n\n<p><a>This seizure is characterized by muscle spasms.<\/a><\/p>\n\n\n\n<p><a>Clonic Seizures<\/a><\/p>\n\n\n\n<p><a><strong>Post-Ictal Phase<\/strong><\/a><\/p>\n\n\n\n<p><a>The post-ictal phase of a seizure can last up to two hours.<\/a><\/p>\n\n\n\n<p><a>True<\/a><\/p>\n\n\n\n<p><a>False<\/a><\/p>\n\n\n\n<p><a>True<\/a><\/p>\n\n\n\n<p><a><strong>Focal Seizure<\/strong><\/a><\/p>\n\n\n\n<p><a>An individual having a focal seizure without dyscognitive features will:<\/a><\/p>\n\n\n\n<p><a>Not be able to interact with the environment<\/a><\/p>\n\n\n\n<p><a>Have gradual loss of consciousness<\/a><\/p>\n\n\n\n<p><a>Have no impairment of consciousness.<\/a><\/p>\n\n\n\n<p><a>Lose cognitive ability momentarily<\/a><\/p>\n\n\n\n<p><a>A lack of dyscognitive features will have no impairment of consciousness.<\/a><\/p>\n\n\n\n<p><a><strong>Febrile Seizures<\/strong><\/a><\/p>\n\n\n\n<p><a>Antiseizure medication is the first line treatment for a febrile seizure.<\/a><\/p>\n\n\n\n<p><a>True<\/a><\/p>\n\n\n\n<p><a>False<\/a><\/p>\n\n\n\n<p><a>false<\/a><\/p>\n\n\n\n<p><a>what are the phases of tonic-clonic seizure<\/a><\/p>\n\n\n\n<p>Tonic-clonic phase (lasts 10-20 seconds): Due to the excessive discharge of neurons in the motor nerves that results in:<br>The muscles of the body become contracted. without any relaxation.<br>Loss of consciousness.<br>Ictal cry. This is a typical sound produced by the tonic contractions of the laryngeal muscles and muscles of expiration.<br>Respiratory impairment that results in cyanosis.<br>Tonic contraction of the jaw muscles that can cause tongue biting.<br>Increased sympathetic activity. This will cause increased heart rate and blood pressure<\/p>\n\n\n\n<p><a><strong>Tension Headache<\/strong><\/a><\/p>\n\n\n\n<p><a>Which of the following is characteristic of a tension headache?<\/a><\/p>\n\n\n\n<p><a>Is the most common type of headache<\/a><\/p>\n\n\n\n<p><a>Is limited to one side of the face<\/a><\/p>\n\n\n\n<p><a>Can be the worst headache experienced<\/a><\/p>\n\n\n\n<p><a>Has associated symptoms<\/a><\/p>\n\n\n\n<p><a>Tension headache is the most common type of headache.<\/a><\/p>\n\n\n\n<p><a>The symptoms of the aural phase of a migraine headache correspond directly to the movement of the cortico-spreading depression across the cerebral cortex.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>This statement is true. The symptoms of the aural phase of a migraine headache correspond directly to the movement of the cortico-spreading depression across the cerebral cortex.<\/a><\/p>\n\n\n\n<p><a>Pharmacological management of a tension headache involves the use of opioids during acute headache<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>Simple analgesics and Non-steroidal anti-inflammatory drugs (NSAIDS) are commonly used for a tension headache.<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/quizlet.com\/explanations\/questions\/true-or-false-pharmacological-management-of-a-tension-headache-involves-the-use-of-opioids-during-acute-headache-83bff9c0-98a82fc1-7dcd-4b32-9962-6dc2b837a57a\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/quizlet.com\/explanations\/questions\/true-or-false-pharmacological-management-of-a-tension-headache-involves-the-use-of-opioids-during-acute-headache-83bff9c0-98a82fc1-7dcd-4b32-9962-6dc2b837a57a\" target=\"_blank\" rel=\"noopener\">We have an expert-written solution to this problem!<\/a><a href=\"https:\/\/quizlet.com\/explanations\/questions\/true-or-false-pharmacological-management-of-a-tension-headache-involves-the-use-of-opioids-during-acute-headache-83bff9c0-98a82fc1-7dcd-4b32-9962-6dc2b837a57a\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p><a>Types of primary headaches<\/a><\/p>\n\n\n\n<p><a>migraine, tension type, cluster, sinus<\/a><\/p>\n\n\n\n<p><a><strong>Secondary Headaches<\/strong><\/a><\/p>\n\n\n\n<p>Secondary headaches are a result of serious underlying diseases. Secondary headaches will consist of warning signs and symptoms. These most often occur in individuals &gt;50 years of age. It is often described as being &#8220;the worst headache of my life&#8221;. It also has the maximum intensity at onset (thunderclap headache). It may also be triggered or worsened by exertion (subarachnoid hemorrhage). Other concerns include decreased level of consciousness, fever, seizure, present concurrently with infection, malignancy, pregnancy, thrombotic therapy or ophthalmological findings (papilledema). You can remember these by the acronym SNOOP:<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/MX7X332rYlS-psb-84c57A.png\" alt=\"Image: Secondary Headaches\"\/><\/figure>\n\n\n\n<p><a>Primary vs secondary headaches<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/fcocL7W2CyOzyi1TFzDrQg.png\" alt=\"Image: Primary vs secondary headaches\"\/><\/figure>\n\n\n\n<p><a>Cluster headaches are a group of idiopathic headaches that are associated with trigeminal neuralgia<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>true<\/a><\/p>\n\n\n\n<p><a>Associated symptoms of a cluster headache include:<br>Nausea and vomiting<br>Lateral neck pain<br>Runny nose, eye redness and tearing<br>Sensitivity to noise<\/a><\/p>\n\n\n\n<p><a>Runny nose, eye redness and tearing are associated with cluster headaches.<\/a><\/p>\n\n\n\n<p><a>Which of the following interventions are used in the treatment of a migraine headache?<br>Non-steroidal anti-inflammatory drugs (NSAIDS) or Aspirin<br>Antiemetic medication<br>Hydration<br>All of the above<\/a><\/p>\n\n\n\n<p><a>all<\/a><\/p>\n\n\n\n<p><a>The facial nerve plays a role in taste sensation in the anterior two-thirds of the tongue.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>This statement is true. The facial nerve plays a role in taste sensation in the anterior two-thirds of the tongue.<\/a><\/p>\n\n\n\n<p><a>Which of the following are signs and symptoms of Bell&#8217;s Palsy?<br>Prominent nasolabial fold<br>Increased taste sensation on the anterior two-thirds of the tongue<br>Drooping mouth and eyelid<br>All of the above<\/a><\/p>\n\n\n\n<p><a>Drooping mouth and eyelid are characteristics signs and symptoms of Bell&#8217;s Palsy.<\/a><\/p>\n\n\n\n<p><a>Bell&#8217;s Palsy is caused by damage to the trigeminal nerve<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>It is caused by damage to the 7th cranial nerve (facial nerve).<\/a><\/p>\n\n\n\n<p><a>The trigeminal nerve (5th cranial nerve) has a motor component and lacks a sensory component<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>The trigeminal nerve has both a motor and sensory component.<\/a><\/p>\n\n\n\n<p><a>Bell Palsy<\/a><\/p>\n\n\n\n<p>Bell&#8217;s palsy involves weakness or paralysis of the muscles on one side of the face that is caused by damage to the 7th cranial nerve (facial nerve). The underlying cause of cranial nerve damage is idiopathic. When there is facial nerve paralysis from a known cause (stroke, tumor, trauma), it is not considered a Bell&#8217;s palsy. Peripheral nerves that emerge from the brain and brain stem are called cranial nerves. Their anatomical location is shown in the diagram below:<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/HCH6EEpze9U.JP1trNfung.png\" alt=\"Image: Bell Palsy\"\/><\/figure>\n\n\n\n<p><a>Symptoms of bell palsy<\/a><\/p>\n\n\n\n<p><a>Absence of a nasolabial fold (runs from the side of the nose to the corner of the mouth)<br>Drooping eyelid<br>Drooping mouth<br>Dryness of the affected eye or mouth<br>Hypersensitivity to loud noises<br>Loss of taste sensation on anterior two-thirds of the tongue.<\/a><\/p>\n\n\n\n<p><a>trigeminal neuralgia<\/a><\/p>\n\n\n\n<p><a>inflammation of the fifth cranial nerve characterized by sudden, intense, brief attacks of sharp pain on one side of the face.<br>The trigeminal nerve is the fifth cranial nerve. It originates from the brain and branches into the ophthalmic branch,maxillary branch, and mandibular branch<\/a><\/p>\n\n\n\n<p><a>Treatment of trigeminal neuralgia involves the use of anticonvulsant medication.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>True<\/a><\/p>\n\n\n\n<p><a>Bell&#8217;s palsy involves an upper motor neuron lesion (False)-<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>Bell&#8217;s palsy involves a lower motor neuron lesion.<\/a><\/p>\n\n\n\n<p><a>Which of the following are characteristic of trigeminal nerve pain?<br>Often attacks suddenly and is intermittent<br>Pain can be incapacitating<br>Pain is described as sharp and stabbing<br>All of the above<\/a><\/p>\n\n\n\n<p><a>all<\/a><\/p>\n\n\n\n<p><a>Which of the following organisms are the most common causes of bacterial meningitis in newborns?<br>Streptococci pneumoniae<br>Group B streptococci<br>Cryptococcus<br>Varicella zoster<\/a><\/p>\n\n\n\n<p><a>Group B streptococci are the most common bacteria causing bacterial meningitis in newborn.<\/a><\/p>\n\n\n\n<p><a>The ability for the bacteria that causes meningitis to exit the primary infection site to enter the meninges is based on the organism&#8217;s virulent factors which include:<br>Colonization<br>Immune Evasion<br>Meningeal invasion<br>All of the above<\/a><\/p>\n\n\n\n<p><a>All affect the virulence of the bacteria.<\/a><\/p>\n\n\n\n<p><a>The cells responsible for producing cerebrospinal fluid (CSF) in the ventricle cavity are:<br>Ependymal cells<br>Synaptic cells<br>Glial cells<br>Nerve cells<\/a><\/p>\n\n\n\n<p><a>The epidymal cells are responsible for producing CSF.<\/a><\/p>\n\n\n\n<p><a>The basement membrane of the blood-brain barrier is surrounded by astrocytes (glial cells).<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>This statement is true. The basement membrane of the blood-brain barrier is surrounded by astrocytes (glial cells).<\/a><\/p>\n\n\n\n<p><a><strong>Meningitis<\/strong><\/a><\/p>\n\n\n\n<p><a>Meningitis is inflammation of the meninges. The meninges are the layers that surround and protect the brain. It can be caused by either a bacteria, virus or fungus<\/a><\/p>\n\n\n\n<p><a>Bacterial Meningitis<\/a><\/p>\n\n\n\n<p><a><strong>Newborns:<\/strong>&nbsp;Group B streptococci; E. Coli; Listeria Monocytogenes<\/a><\/p>\n\n\n\n<p><a><strong>Children and Teens<\/strong>: Neisseria Meningitidis; Streptococcus Pneumoniae<\/a><\/p>\n\n\n\n<p><a>Streptococcus Pneumoniae; Listeria Monocytogenes<\/a><\/p>\n\n\n\n<p><a>viral meningitis<\/a><\/p>\n\n\n\n<p><a><strong>More common:<\/strong>Enteroviruses, Herpes simplex, HIV<\/a><\/p>\n\n\n\n<p><a><strong>Less common:<\/strong>&nbsp;Mumps, varicella zoster, lymphocytic choriomeningitis<\/a><\/p>\n\n\n\n<p><a>Fungal meningitis<\/a><\/p>\n\n\n\n<p><a><strong>Affects immunocompromised:<\/strong><\/a><\/p>\n\n\n\n<p><a>Cryptococcus<\/a><\/p>\n\n\n\n<p><a>Coccidioides genuses<\/a><\/p>\n\n\n\n<p><a><strong>Tubercular Meningitis:<\/strong>&nbsp;Mycobacterium tuberculosis<\/a><\/p>\n\n\n\n<p><a><strong>Parasitic Meningitis:<\/strong>P. Falciparum<\/a><\/p>\n\n\n\n<p><a><strong>Pathophysiology of Meningitis<\/strong><\/a><\/p>\n\n\n\n<p>In bacterial meningitis, the bacteria from the primary source allow it to enter the meninges based on the its virulent factors.:<br>Colonization: the bacteria&#8217;s ability to colonize the area. For example, the bacteria streptococcus pneumoniae can break down the hosts&#8217; antibodies using IgA proteins which breaks down the mucosal antibody IgA. This allows bacteria to colonize the area. Some bacteria also have pili or fimbriae that allows them to attach to the host&#8217;s epithelium and invade the area. At this point, the bacteria cause the infection. We can say that this is the primary infection, whether it is pneumonia or sinusitis. Some bacteria have virulent factors or mechanisms that allow them to invade.<br>Immune evasion: some bacteria have virulent factors or mechanisms that allow them to evade the immune system. For example, the bacteria group B streptococcus and streptococcus pneumoniae have a capsule that allow it to evade macrophages as well as complement factors. The bacteria can enter the blood stream that causes bacteremia allowing it to travel towards the brain. This is known as hematogenous spread. It is important to know that the bacteria can invade the meninges directly from sinusitis, pneumonia or it can go through the cerebrospinal fluid.<br>Meningeal invasion: Let&#8217;s focus on the cerebral spinal fluid (CSF). The CSF is produced in the brain by the lateral ventricle and provides nourishment for the brain tissues. After production, it flows to the third ventricles then to the fourth ventricle. From the fourth ventricle it enters the subarachnoid space. From the subarachnoid space, it will go through arachnoid granulation and enter the venous sinus. The venous sinus are the big veins that transport the blood back to the heart.<br>The brain is protected by the blood-brain barrier which is a semi-permeable membrane barrier that separates circulation from the brain and prevents substances from getting inside the brain. Blood vessels are composed of endothelial cells. The endothelial cells are surrounded by the basement membrane. The basement membrane is surrounded by astrocytes (glial cells). These are the brain&#8217;s supporting cells. This formation only allows certain things to pass through to the brain. The blood brain barrier allows glucose and oxygen to get inside the brain.<\/p>\n\n\n\n<p><a>Arachnoid Space<br>Let&#8217;s focus even further into the arachnoid space. The dura mater is located below the skull. The arachnoid membrane is located below the dura mater followed by the arachnoid space.<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/U71-dGxp5epwEglbxgkPqA.png\" alt=\"Image: Arachnoid Space\nLet's focus even further into the arachnoid space. The dura mater is located below the skull. The arachnoid membrane is located below the dura mater followed by the arachnoid space.\"\/><\/figure>\n\n\n\n<p><a><strong>Clinical Manifestations of Meningitis<\/strong><\/a><\/p>\n\n\n\n<p><a><strong>Clinical Manifestations of Meningitis<\/strong><\/a><\/p>\n\n\n\n<p><a>There is a triad of classic meningitis symptoms:<\/a><\/p>\n\n\n\n<p><a>Headache<\/a><\/p>\n\n\n\n<p><a>Fever<\/a><\/p>\n\n\n\n<p><a>Nuchal rigidity (neck stiffness)<\/a><\/p>\n\n\n\n<p><a>Other symptoms:<\/a><\/p>\n\n\n\n<p><a>Photophobia<\/a><\/p>\n\n\n\n<p><a>Phonophobia<\/a><\/p>\n\n\n\n<p><a>Meningoencephalitis:<\/a><\/p>\n\n\n\n<p><a>Altered mental state<\/a><\/p>\n\n\n\n<p><a>Seizures<\/a><\/p>\n\n\n\n<p><a><strong>Meningitis Diagnosis<\/strong><\/a><\/p>\n\n\n\n<p>Physical exam: Kernig&#8217;s sign Brudzinski&#8217;s sign<br>Lumbar puncture: if meningitis is suspected: Measures pressure Analyze CSF: WBCs, protein, and glucose<br>Polymerase Chain Reaction (PCR): can be used to identify specific causes of the meningitis (HIV, enteroviruses, HSV, or tuberculosis). If the specific cause is identified, a test for it may be used. For example: The Western Blot for Borrelia Burgdorferi Thin blood smear for malaria<\/p>\n\n\n\n<p><a>meninigis treatment<\/a><\/p>\n\n\n\n<p><strong>Treatment<\/strong><\/p>\n\n\n\n<p>The treatment of meningitis depends on the underlying cause.<\/p>\n\n\n\n<p>Bacterial: Steroids followed by antibiotics to prevent massive injury the leptomeninges from the inflammation that can be caused as the antibiotics destroy the bacteria.<\/p>\n\n\n\n<p>In general, drug treatments using antivirals, antibiotics, antifungals and antiparasitic drugs are aimed at a specific cause of meningitis<\/p>\n\n\n\n<p>Prevention: a vaccine can be given for some causes such as Neisseria meningitis, mumps and disseminated tuberculosis.<\/p>\n\n\n\n<p>Prophylactic antibiotics: to avoid outbreaks of bacterial meningitis<\/p>\n\n\n\n<p><a>Kernig&#8217;s sign<\/a><\/p>\n\n\n\n<p><a>Kernig&#8217;s is performed by having the supine patient, with&nbsp;<strong>hips and knees flexed, extend the leg passively<\/strong>. pain upon extension is a positive sign<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/gTom19WddI7d37MyzzmL7A.png\" alt=\"Image: Kernig's sign\"\/><\/figure>\n\n\n\n<p><a>The Brudzinski&#8217;s sign<\/a><\/p>\n\n\n\n<p><a>The Brudzinski&#8217;s sign is positive when passive forward flexion of the neck causes the patient to involuntarily raise his knees or hips in flexion.<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/gTom19WddI7d37MyzzmL7A.png\" alt=\"Image: The Brudzinski's sign\"\/><\/figure>\n\n\n\n<p><a>The meninges are pain sensitive.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>This statement is true. The meninges are pain sensitive.<\/a><\/p>\n\n\n\n<p><a><strong>Polymerase Chain Reaction<\/strong><\/a><\/p>\n\n\n\n<p><a>Polymerase Chain Reaction (PCR) test is used to differentiate between bacterial and viral meningitis<\/a><\/p>\n\n\n\n<p><a>True<\/a><\/p>\n\n\n\n<p><a>False<\/a><\/p>\n\n\n\n<p><a>It is used to establish the cause of the meningitis.<\/a><\/p>\n\n\n\n<p><a>Which of the following is one of the layers of the meninges?<br>Dura mater<br>Pia<br>Arachnoid membrane<br>All of the above<\/a><\/p>\n\n\n\n<p><a>all<\/a><\/p>\n\n\n\n<p><a>Which of the following are part of the triad of classic symptoms of meningitis?<br>Hypothermia<br>Ptosis<br>Neck flaccidity<br>Nuchal rigidity<\/a><\/p>\n\n\n\n<p><a>Nuchal rigidity is the only symptom listed that is part of the triad of classic symptoms of meningitis.<\/a><\/p>\n\n\n\n<p><a><strong>Subclavian Steal Syndrome<\/strong><\/a><\/p>\n\n\n\n<p><a>Subclavian steal syndrome is characterized by:<\/a><\/p>\n\n\n\n<p><a>Hemianopia.<\/a><\/p>\n\n\n\n<p><a>Symptomatic at rest and with activity at the onset of subclavian artery blockage.<\/a><\/p>\n\n\n\n<p><a>Pain in the occipital area.<\/a><\/p>\n\n\n\n<p><a>Asymptomatic until the patient engages in arm movement.<\/a><\/p>\n\n\n\n<p><a>Individuals with subclavian steal syndrome will be asymptomatic until they engage in arm movement.<\/a><\/p>\n\n\n\n<p><a>In atherosclerosis of the vertebral arteries, that patient will report pain in neck or occipital area<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>This statement is true. In atherosclerosis of the vertebral arteries, that patient will report pain in neck or occipital area.<\/a><\/p>\n\n\n\n<p><a>Choose the following that are part of the posterior cerebral circulation:<br>Posterior Inferior cerebellar artery (PICA)<br>Vertebral arteries<br>Middle cerebral artery<br>Posterior cerebral artery<br>Anterior cerebral artery<br>Superior cerebellar artery<br>Basilar artery<\/a><\/p>\n\n\n\n<p><a>Parts of the posterior cerebral circulation include:<br>Vertebral arteries<br>Posterior Inferior cerebellar artery (PICA)<br>Basilar artery<br>Superior cerebellar artery<br>Posterior cerebral artery<\/a><\/p>\n\n\n\n<p><a>vessel involvement<\/a><\/p>\n\n\n\n<p><a><strong>Anterior Cerebral Artery<\/strong><\/a><\/p>\n\n\n\n<p><a><strong>Motor and sensory deficit:<\/strong><\/a><\/p>\n\n\n\n<p><a>Lower extremities: (leg and foot)<\/a><\/p>\n\n\n\n<p><a>Slight upper extremity involvement<\/a><\/p>\n\n\n\n<p><a>Contralateral<\/a><\/p>\n\n\n\n<p><a><strong>Middle Cerebral Artery<\/strong><\/a><\/p>\n\n\n\n<p><a><strong>Motor and sensory deficit:<\/strong><\/a><\/p>\n\n\n\n<p><a>Upper extremities and face<\/a><\/p>\n\n\n\n<p><a>Contralateral<\/a><\/p>\n\n\n\n<p><a>Decrease in conjugate gaze<\/a><\/p>\n\n\n\n<p><a>Homonymous hemianopia (decreased vision on one half of both sides)<\/a><\/p>\n\n\n\n<p><a>Speech (motor): aphasia<\/a><\/p>\n\n\n\n<p><a><strong>Transient Ischemic Attack (TIA)<\/strong><\/a><\/p>\n\n\n\n<p>A transient ischemic attack (TIA) is an episode of neurological dysfunction. If an infarction does not occur, it is a TIA (reversible ischemia). If an infarction does occur, then it is a stroke (irreversible infarct). A TIA increases the risk for a future stroke. It can be associated with sudden onsets of syncope, amnesia or seizures. Risk factors for a TIA include:<br>Hypertension<br>Atherosclerosis<br>Diabetes mellitus<br>Obesity<br>Hypercoagulable states<br>Amyloid angiopathy<br>Atrial fibrillation<br>Myocardial infarction<br>Previous TIA<br>Valvular disease<\/p>\n\n\n\n<p><a>TIA pathophysiology<\/a><\/p>\n\n\n\n<p><strong>Anterior Circulation:<\/strong>&nbsp;the first artery encountered in the anterior circulation is the internal carotid artery. There is a branch from the internal carotid artery to the ophthalmic artery that innervates the eyeball. Sometimes when there is a TIA involving the ophthalmic artery, the patient may present with ocular blindness. The internal carotid artery continues to the Circle of Willis and branches into the anterior towards the brain between the two hemispheres. It also splits into the middle cerebral artery on the side of the brain<\/p>\n\n\n\n<p><strong>Posterior Circulation:<\/strong>&nbsp;The posterior circulation: starts at the vertebral arteries and continues into the back of the brain.<\/p>\n\n\n\n<p>Vertebral arteries (two): posterior circulation starts here and continues to the back of the brain<\/p>\n\n\n\n<p>Posterior Inferior cerebellar artery (PICA): it supplies the posterior brain and inferior cerebellum. Blood then circulates to the dura mater and eventually becomes:<\/p>\n\n\n\n<p>Basilar artery: the two vertebral arteries converge to form one basilar artery.<\/p>\n\n\n\n<p>Superior cerebellar artery<\/p>\n\n\n\n<p>Posterior cerebral artery<\/p>\n\n\n\n<p><a>CVA<\/a><\/p>\n\n\n\n<p>Cerebrovascular Accident (CVA)<br>Ischemic stroke: is due to decreased blood flow to the brain due to an embolus that may originate from:<br>Cardiogenic: it begins in the heart. The embolus can break and travel into the aorta to the carotid artery and continue moving on into either the anterior cerebral artery or the middle cerebral artery.<\/p>\n\n\n\n<p><a><strong>Clinical Manifestations of Ischemic Stroke<\/strong><\/a><\/p>\n\n\n\n<p><strong>Anterior circulation:<\/strong><\/p>\n\n\n\n<p>Internal carotid artery: an atherosclerotic plaque is commonly involved that leads to a decreased blood flow to the area. The patient is typically asymptomatic because the Circle of Willis can compensate for diminished blood flow for the lack of blood flow on one side. To exhibit symptoms, both the carotid arteries would have to exhibit diminished blood flow. However, the patient may present with ocular blindness because of the disruption of blood flow to the ophthalmic artery. Clinically, there will be a high-pitched carotid bruit identified on exam.<\/p>\n\n\n\n<p><a>anterior cerebral artery<\/a><\/p>\n\n\n\n<p><a>Anterior Cerebral Artery<\/a><\/p>\n\n\n\n<p><a><strong>Motor and sensory deficit:<\/strong><\/a><\/p>\n\n\n\n<p><a>Lower extremities: (leg and foot)<\/a><\/p>\n\n\n\n<p><a>Slight upper extremity involvement<\/a><\/p>\n\n\n\n<p><a>Contralateral<\/a><\/p>\n\n\n\n<p><a><strong>Urinary incontinence<\/strong><\/a><\/p>\n\n\n\n<p><a><strong>Abulia: lack of will<\/strong>: due to some frontal lobe involvement<\/a><\/p>\n\n\n\n<p><a>Middle cerebral artery<\/a><\/p>\n\n\n\n<p><a><strong>Motor and sensory deficit:<\/strong><\/a><\/p>\n\n\n\n<p><a>Upper extremities and face<\/a><\/p>\n\n\n\n<p><a>Contralateral<\/a><\/p>\n\n\n\n<p><a>Decrease in conjugate gaze<\/a><\/p>\n\n\n\n<p><a>Homonymous hemianopia (decreased vision on one half of both sides)<\/a><\/p>\n\n\n\n<p><a><strong>Dominant side symptoms<\/strong><\/a><\/p>\n\n\n\n<p><a>Speech (motor): aphasia<\/a><\/p>\n\n\n\n<p><a><strong>Non-dominant side symptoms:<\/strong><\/a><\/p>\n\n\n\n<p><a>Neglect<\/a><\/p>\n\n\n\n<p><a>Anosognosia<\/a><\/p>\n\n\n\n<p><a><strong>Posterior Circulation<\/strong><\/a><\/p>\n\n\n\n<p>The posterior circulation supplies the entire brainstem, cerebellum and spine. There are two vertebral arteries that eventually form the single basilar artery. Before branching out to form the basilar artery it gives branch to the posterior cerebral artery shown in the diagram below. The area of the brain supplied by the posterior cerebral artery is shaded in blue in the second diagram. The anterior inferior cerebellar artery and then splits into the superior cerebellar arteries. This comprises the entire brainstem and is controlled by the posterior circulation.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/NOWVrS1QVUyGxbATCpwO6g.png\" alt=\"Image: Posterior Circulation\"\/><\/figure>\n\n\n\n<p><a><strong>Vertebral Arteries<\/strong><\/a><\/p>\n\n\n\n<p>Extracranial: Subclavian steal syndrome: as you locate the subclavian artery below note that with this syndrome, there will be a blockage in the subclavian artery. Also note that one of the first branches of the subclavian artery is the vertebral artery that eventually come together to form the basilar artery. When there is a subclavian artery blockage, the patient will be asymptomatic. But when the individual begins to use their arms (e.g. during exercise), there is more blood flow required and instead of traveling up, travels down. The patient will experience dizziness, diplopia due to decreased circulation to the posterior cerebral artery. They may have staggering due to lack of blood flow to the cerebellum. Atherosclerosis of the vertebral arteries: the patient will report pain in the neck or in the occipital area. There may also be some minor complaints of dizziness and hemianopia as the severity increases. A bruit may be heard in the supraclavicular region or the posterior cervical muscles since the vertebral artery goes through the vertebrae.<\/p>\n\n\n\n<p><a>Lateral Medullary Syndrome (Sensory Symptoms)<\/a><\/p>\n\n\n\n<p><strong>Wallenberg syndrome:<\/strong>&nbsp;involves the posterior-inferior cerebellar artery<\/p>\n\n\n\n<p>e.g. if lesion is on the left brain<\/p>\n\n\n\n<p>Symptoms: face symptoms will be ipsilateral to the lesion. In the rest of the body, symptoms will be on the right side (contralateral):<\/p>\n\n\n\n<p>Face symptoms: pain and numbness related to the trigeminal nerve (5th cranial nerve); nystagmus; diplopia; vertigo; nausea and vomiting<\/p>\n\n\n\n<p>Body symptoms: Decreased pain and temperature sensation in the lower extremities due to major effect on spinothalamic area.<\/p>\n\n\n\n<p>Dysphagia*<\/p>\n\n\n\n<p>Hoarseness*<\/p>\n\n\n\n<p>Decreased gag reflex*<\/p>\n\n\n\n<p>*9th and 10th cranial nerves<\/p>\n\n\n\n<p><a><strong>Medial Medullary Syndrome (Motor Symptoms)<\/strong><\/a><\/p>\n\n\n\n<p>Involves the anterior spinal artery<br>e.g. If lesion is on the left brain<br>Symptoms: face symptoms will be ipsilateral to lesion. In the rest of the body, symptoms will be on the right side (contralateral)<br>Face symptoms: tongue paralysis (12th cranial nerve)<br>Body symptoms: paralysis of the entire body on affected side and decreased proprioception<\/p>\n\n\n\n<p><a><strong>Basilar Artery and Midbrain Syndrome<\/strong><\/a><\/p>\n\n\n\n<p><a><strong>Basilar Artery Syndrome<\/strong><\/a><\/p>\n\n\n\n<p><a>Affects the pons area of the brain. Locked in syndrome indicates that the patient cannot move or talk, but their sensory functions are intact. The only intact motor movement is eye movement.<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/Cj4AKLKdPnB1fRCbIYJ8sg.png\" alt=\"Image: Basilar Artery and Midbrain Syndrome\"\/><\/figure>\n\n\n\n<p><a>Midbrain syndrome (Weber&#8217;s syndrome)<\/a><\/p>\n\n\n\n<p><a>Affects 3rd cranial nerve, the ocular motor nerve (ptosis); eye is also down and out as shown in the individual&#8217;s right eye below:<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/jC5owQ0X20vMvKgRDSg7rQ.png\" alt=\"Image: Midbrain syndrome (Weber's syndrome)\"\/><\/figure>\n\n\n\n<p><a><strong>Treatment of TIA and Ischemic Stroke<\/strong><\/a><\/p>\n\n\n\n<p>Management of the patient will occur in the acute care setting. Perform stabilizing measures if necessary: Check airway, breathing and circulation Check vital signs Obtain blood glucose level Arterial blood gas<br>Obtain CT scan without contrast to rule out hemorrhagic stroke<br>If hemorrhagic stroke is ruled out, the individual would receive thrombolytic therapy or thrombectomy<br>To identify the cause of the stroke: Duplex ultrasound and doppler of cerebral arteries MRI-to visual smaller cerebral arteries Cardiac evaluation to identify valve disorders, thrombus ECG and holter monitor (to identify A-fib)<br>Our next focus is on the hemorrhagic stroke which requires a different type of management from that of the ischemic stroke.<\/p>\n\n\n\n<p><a><strong>Hemorrhagic Stroke<\/strong><\/a><\/p>\n\n\n\n<p><strong>Hemorrhagic Stroke<\/strong><\/p>\n\n\n\n<p>Hemorrhagic stroke is caused by a rupture of a blood vessel that leads to a hemorrhage. It accounts for approximately 10-15% of all strokes. Cause can be related to long-standing hypertension or venous malformation. The location of the hemorrhage may be inside the brain parenchyma (intracerebral) or in the subarachnoid or subdural spaces.<\/p>\n\n\n\n<p><strong>Etiology<\/strong><\/p>\n\n\n\n<p>Primary hypertensive hemorrhage: Uncontrolled hypertension weakens the arterial wall. The most common site is the basal ganglia. There will be dilation of the arterial wall<\/p>\n\n\n\n<p>Secondary to ruptured arteriovenous malformation (AVM) or aneurysm<\/p>\n\n\n\n<p>Subdural hematoma due to trauma<\/p>\n\n\n\n<p><strong>Pathophysiology<\/strong><\/p>\n\n\n\n<p>A hemorrhage involves a mass of formed blood. Brain tissue that is adjacent to the hemorrhage becomes compressed which leads to ischemia, edema (due to neutrophil activity in the area) and increased intracranial pressure. The hemorrhage will typically resolve through reabsorption. The macrophages and astrocytes play a role in clearing the blood from the area followed by formation of a cavity surrounded by a thick glial scar. A massive hemorrhage may be fatal.<\/p>\n\n\n\n<p><a><strong>Clinical Manifestations of Hemorrhagic Stroke<\/strong><\/a><\/p>\n\n\n\n<p>The clinical manifestations are like an ischemic stroke and depend on the location and size of the bleed. An individual with an intracranial hemorrhage due to a leaking or ruptured aneurysm may present with one of the three sets of symptoms below:<br>&#8220;Worst headache of my life&#8221;-excruciating generalized headache with onset of immediate unresponsive state<br>Onset of headache with no loss of consciousness<br>Sudden onset of unconsciousness<br>Typically, there may be no local signs if the hemorrhage is confined to the subarachnoid space. If it is not confined, bleeding spreads into the brain tissue to cause hemiparesis\/paralysis, aphasia or homonymous hemianopsia.<br>The role of the NP may involve recognizing the warning signs of an impending rupture of the aneurysm which include transient unilateral weakness, numbness and tingling. There may also be transient aphasia. Prompt referral to the emergency department and a neurologist is indicated. The NP should also be aware that the American Heart Association\/American Stroke Association provided clinical guidelines for the management of intracerebral hemorrhage.<\/p>\n\n\n\n<p><a><strong>Diagnosis of Hemorrhagic Stroke<\/strong><\/a><\/p>\n\n\n\n<p>The following factors will guide the diagnosis of a hemorrhagic stroke:<br>Health history<br>Clinical presentation<br>Laboratory tests<br>Neurological imaging procedures CT and MRI<br>First, treatment must be initiated within 3-4 hours of the onset of symptoms in order to reverse brain ischemia. This further underscores the need for the NP to perform a thorough health history and symptom analysis. If signs point to a hemorrhagic stroke, then again, prompt referral is necessary.<\/p>\n\n\n\n<p><a><strong>Treatment of Hemorrhagic Stroke<\/strong><\/a><\/p>\n\n\n\n<p><a>Reduction or cessation of the bleeding<br>Controlling cerebral edema to prevent increased intracranial pressure<br>Prevention of the development of a future bleed<br>Prevention of vasospasm<br>Prevention and\/or control of seizures<\/a><\/p>\n\n\n\n<p><a>A hemorrhagic stroke confined to the subarachnoid space will present with no local signs.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>This statement is true. A hemorrhagic stroke confined to the subarachnoid space will present with no local signs.<\/a><\/p>\n\n\n\n<p><a>Which of the following relate to medial medullary syndrome?<br>Facial symptoms ipsilateral to the lesion<br>Body symptoms contralateral to the lesion<br>Decreased proprioception<br>All of the above<\/a><\/p>\n\n\n\n<p><a>all<\/a><\/p>\n\n\n\n<p><a>The onset of hemiparesis, aphasia or homonymous hemianopsia in a hemorrhagic stroke indicates that the bleed is not confined to the subarachnoid space.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>This statement is true. The onset of hemiparesis, aphasia or homonymous hemianopsia in a hemorrhagic stroke indicates that the bleed is not confined to the subarachnoid space.<\/a><\/p>\n\n\n\n<p><a>An individual with an intracranial hemorrhage due to a leaking or ruptured aneurysm may present with:<br>Worst headache of their life<br>Onset of headache with no loss of consciousness<br>Sudden onset of unconsciousness<br>All of the above<\/a><\/p>\n\n\n\n<p><a>Which of the following microbes plays a role in the development of rosacea?<br>Demodex mites<br>H. pylori<br>Staphylococcal organisms<br>All of the above<\/a><\/p>\n\n\n\n<p><a>All play a role in the development of rosacea.<\/a><\/p>\n\n\n\n<p><a>Rosacea is characterized by an itchy facial rash that:<br>Is alleviated with the use of topical creams<br>Is typically related to starting a new medication<br>Is contagious<br>Stings and burns<\/a><\/p>\n\n\n\n<p><a>Rosacea is characterized by stinging and burning facial rash. None of the other choices are true of rosacea.<\/a><\/p>\n\n\n\n<p><a>Factors that can trigger rosacea include:<\/a><\/p>\n\n\n\n<p><a>Exposure to extreme temperatures<br>Strenuous exercise<br>Severe sunburn<br>Stress and anxiety<br>Cold wind<br>Hot and spicy foods<br>Alcohol ingestion<br>Foods and beverages that contain caffeine<br>Other triggering factors include:<br>Medications<br>H. pylori<br>Demodex mites<br>Presence of cathelicidin<\/a><\/p>\n\n\n\n<p><a>Erythematotelangiectatic rosacea is characterized by persistent central\/facial erythema and telangiectasias.<br>True or False<\/a><\/p>\n\n\n\n<p><a>This statement is true. Erythematotelangiectatic rosacea is characterized by persistent central\/facial erythema and telangiectasias.<\/a><\/p>\n\n\n\n<p><a><strong>Pathophysiology of Rosacea<\/strong><\/a><\/p>\n\n\n\n<p>Although the exact cause of rosacea is unknown, there are several theories that may help to explain its underlying causes:<br>Aberrant innate immune system: Activation of the innate immune system causes the release of cytokines and antimicrobial molecules such as peptide cathelicidin. They also envelope viruses and fungi. In rosacea, the peptide cathelicidin is unregulated and therefore, leads to an over response of the innate immune system.<br>Ultraviolet radiation: this is thought to trigger angiogenesis and increase production of reactive oxygen species that leads to upregulation of matrix metalloproteinases (MMPs) that result is damage to the blood vessels and dermal matrix. MMPs are a group of enzymes responsible for the breakdown of most extracellular proteins during organogenesis, growth and normal tissue turnover.<br>Vascular changes: there is increased blood flow in skin with associated flushing with rosacea that may be the result of an elevated expression of vascular endothelial growth factor (VEGF) and lymphatic endothelial markers that suggests stimulation of blood vascular and lymphatic endothelial cells.<br>Epidermal barrier dysfunction: there is increased epidermal water loss which allows for the skin to become irritated easily<br>Neurogenic inflammation: the sensory nerves release mediators at the site of inflammation that results in vasodilation and loss of plasma proteins. Inflammatory cells are also recruited to the area. This mechanism is not well-understood.<br>Microbes: Demodex mites: part of normal skin but are found in abundance in patients with rosacea. Infestation is associated with infiltration of CD4+ helper cells H. pylori Staphylococcal organisms: is thought to play a role in the development of rosacea but not exactly clear about how.<\/p>\n\n\n\n<p><a>Ultraviolet radiation contributes to the development of rosacea because:<br>Causes the production of peptide cathelicidin<br>Increases the production of matrix metalloproteinases (MMPs)<br>It stops the effects of angiogenesis<br>Causes sensory nerves to release chemical mediators at the site of inflammation<\/a><\/p>\n\n\n\n<p><a>Increases the production of matrix metalloproteinases (MMPs)<\/a><\/p>\n\n\n\n<p><a>Which of the following is part of the pathogenesis of acne vulgaris?<br>Infection with staph. Aureus<br>Excess sebum production<br>Follicular hypoproliferation<br>All of the above<\/a><\/p>\n\n\n\n<p><a>Excess sebum production is part of the pathogenesis of acne vulgaris.<\/a><\/p>\n\n\n\n<p><a>Which of factors below can worsen acne?<br>Increased androgen levels<br>Stress<br>Family history<br>All of the above<\/a><\/p>\n\n\n\n<p><a>All<\/a><\/p>\n\n\n\n<p><a>An example of a closed comedone lesion is a blackhead<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>(False)- it is an example of a whitehead.<\/a><\/p>\n\n\n\n<p><a>What drugs can exacerbate acne?<\/a><\/p>\n\n\n\n<p><a>corticosteriods, anticunvulsants, barbituates, androgenic steroids.<\/a><\/p>\n\n\n\n<p><a>The skin lesions of acne may be classified as non-inflammatory lesions and inflammatory lesions.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>This statement is true. The skin lesions of acne may be classified as non-inflammatory lesions and inflammatory lesions.<\/a><\/p>\n\n\n\n<p><a>Acne pathophysiology<\/a><\/p>\n\n\n\n<p><a><strong>Pathophysiology<\/strong><\/a><\/p>\n\n\n\n<p><a>There are several components in the pathogenesis of acne vulgaris: Infection with propionibacterium acnes: Gram-positive bacteria<\/a><\/p>\n\n\n\n<p><a>Is also known as cutibacterium acnes<\/a><\/p>\n\n\n\n<p><a>Follicular hyperproliferation<\/a><\/p>\n\n\n\n<p><a>Excess sebum production: sebum is skin oil<\/a><\/p>\n\n\n\n<p><a>Inflammation<\/a><\/p>\n\n\n\n<p><a>Drugs that exacerbate acne<\/a><\/p>\n\n\n\n<p><a>Some drugs may also exacerbate acne:<br>Phenytoin<br>Isoniazid<br>Lithium<br>Glucocorticoids<br>Cyclosporin<br>Disulfiram<br>Azothioprine<br>EGFR inhibitors<\/a><\/p>\n\n\n\n<p><a>Associated conditions that can cause acne include polycystic ovary syndrome and tumors of the adrenal glands and ovaries.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>Associated conditions that can cause acne include polycystic ovary syndrome and tumors of the adrenal glands and ovaries.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>Blackheads are open pores that contain oxidized lipids.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>True<\/a><\/p>\n\n\n\n<p><a>Which of the following drug may be used in the treatment of acne?<br>Topical retinoid<br>Cortisone cream<br>Steroids<br>All of the above<\/a><\/p>\n\n\n\n<p><a>topical retinoid<\/a><\/p>\n\n\n\n<p><a>Which of the following is characteristic of a basal cell carcinoma?<br>Is the most common form of skin cancer<br>Are slow-growing localized tumors<br>Lesion is shiny, elevated and well-circumscribed<br>All of the above<\/a><\/p>\n\n\n\n<p><a>All are characteristic of a basal cell carcinoma.<\/a><\/p>\n\n\n\n<p><a>Which of the following is characteristic of a squamous cell carcinoma?<br>Is the second most common form of skin cancer<br>Lesions are irregular and not well-defined<br>Originates from a mole<br>All of the above<\/a><\/p>\n\n\n\n<p><a>It is the second most common form of skin cancer.<\/a><\/p>\n\n\n\n<p><a>Actinic keratosis is a precursor to squamous cell carcinoma.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>true<\/a><\/p>\n\n\n\n<p><a>Melanomas grow horizontally within the epidermis and superficial dermis as well as vertically to invade the dermis.<br>True<br>False<\/a><\/p>\n\n\n\n<p><a>This statement is true. Melanomas grow horizontally within the epidermis and superficial dermis as well as vertically to invade the dermis.<\/a><\/p>\n\n\n\n<p><a>The biggest environmental factor that contributes to the development of skin cancer is:<br>Immunosuppression<br>UV light exposure from the sun or tanning booth<br>Human papilloma virus (HPV)<br>Light pigmented skin<\/a><\/p>\n\n\n\n<p><a>UV light exposure from the sun and tanning booths are the biggest contributors of skin cancer development.<\/a><\/p>\n\n\n\n<p><a><strong>Basal Cell Carcinoma<\/strong><\/a><\/p>\n\n\n\n<p><strong>Basal Cell Carcinoma<\/strong><\/p>\n\n\n\n<p>Basal cell carcinoma is the most common skin cancer and involves cells in the stratum basale. These are slow-growing tumors that are locally invasive and rarely metastasize. Blood vessels in the near-by dermis can become dilated to deliver more nutrients as the tumor grows (see diagram below of a basal cell carcinoma). Basal cell carcinomas can also grow superficially as they spread several centimeters over the epidermis. They can also break down the basal membrane and enter the dermis forming islands or cords of tumor cells.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/xkpTGEkiAKa8KeTUsP.TtQ.png\" alt=\"Image: Basal Cell Carcinoma\"\/><\/figure>\n\n\n\n<p><a>Squamous cell carcinoma<\/a><\/p>\n\n\n\n<p>Squamous cell carcinoma is the second most common cause of skin cancer which involves squamous keratinocytes. There is a precancerous lesion that can turn into squamous cell carcinoma. This is known as actinic keratosis where keratinocytes are damaged by radiation and begin to overproduce keratin. Over time, the damaged keratinocytes can develop into squamous cell carcinoma.<br>The early stage of squamous cell carcinoma is also known as Bowen&#8217;s disease or squamous cell carcinoma in situ. At this point, the tumor can be found in the epidermis but has not yet broken through the basement membrane. The tumor cells are atypical, enlarged and over-pigmented. As squamous cell carcinoma becomes more invasive, it can break through the basement membrane and extend into the dermis and even the hypodermis. At this point, it is more likely to metastasize. Tumor cells at the advanced stages vary in their degree of maturity, have abnormal shapes and overproduce keratin to form pearls.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/quizlet.com\/cdn-cgi\/image\/f=auto,fit=cover,h=200,onerror=redirect,w=240\/https:\/\/o.quizlet.com\/TcMrvg68kvqYfN3AIf3HnQ.png\" alt=\"Image: Squamous cell carcinoma\"\/><\/figure>\n\n\n\n<p><a>Melanoma Acronym<\/a><\/p>\n\n\n\n<p><a>Asymmetrical lesions<br>Borders are irregular or notched<br>Coloration varies within the same lesion<br>Diameter is larger than the size of a pencil eraser<br>Evolves rapidly over time and causes skin elevation.<\/a><\/p>\n\n\n\n<p><a>Which of the following phrases appropriately describes the border of a lesion of a melanoma?<br>Are irregular and notched<br>Is asymmetric<br>Causes skin elevation<br>Is larger than the size of a pencil eraser<\/a><\/p>\n\n\n\n<p><a>Are irregular and notched<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>NR507 \/ NR 507 Week 8 Exam Q &amp; A (Latest 2024 \/ 2025): Advanced Pathophysiology &#8211; Chamberlain NR-507 Advanced PathophysiologyWeek 8 Exam Q &amp; Atrigeminal neuralgiaCorrect Answer:inflammation of the fifth cranial nerve characterized by sudden, intense,brief attacks of sharp pain on one side of the face.The trigeminal nerve is the fifth cranial nerve. It [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[25],"tags":[],"class_list":["post-131020","post","type-post","status-publish","format-standard","hentry","category-exams-certification"],"_links":{"self":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/131020","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/comments?post=131020"}],"version-history":[{"count":0,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/131020\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/media?parent=131020"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/categories?post=131020"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/tags?post=131020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}