A nurse is teaching a client who has osteoarthritis and is prescribed celecoxib (Celebrex), a selective COX-2 inhibitor. What should the nurse include in the teaching?<\/p>\n\n\n\n
A. The drug has less gastrointestinal toxicity than nonselective COX inhibitors because it does not interfere with gastric mucosal protection by prostaglandins.
B. The drug has more anti-inflammatory and analgesic effects than nonselective COX inhibitors because it blocks both COX-1 and COX-2 enzymes.
C. The drug has less cardiovascular risk than nonselective COX inhibitors because it inhibits vasodilatory and antiplatelet prostaglandins produced by COX-2 in the endothelium.
D. The drug has more antipyretic and antiplatelet effects than nonselective COX inhibitors because it blocks the production of prostaglandins involved in fever and platelet aggregation.<\/p>\n\n\n\n
The Correct Answer and Explanation is :<\/mark><\/strong><\/p>\n\n\n\n The correct answer is A. The drug has less gastrointestinal toxicity than nonselective COX inhibitors because it does not interfere with gastric mucosal protection by prostaglandins.<\/strong><\/p>\n\n\n\n Celecoxib (Celebrex) is a selective COX-2 inhibitor, meaning it specifically targets the COX-2 enzyme while sparing COX-1. To understand the implications of this selectivity, it’s essential to differentiate between the two cyclooxygenase (COX) enzymes and their functions.<\/p>\n\n\n\n COX-1<\/strong> is involved in the production of prostaglandins that have protective effects on the gastric mucosa, including maintaining the integrity of the stomach lining and promoting mucus secretion. These prostaglandins help protect the stomach from damage caused by gastric acids. COX-2<\/strong>, on the other hand, is primarily involved in the inflammatory response and pain.<\/p>\n\n\n\n Traditional nonselective COX inhibitors (like ibuprofen or naproxen) block both COX-1 and COX-2 enzymes. While this dual inhibition helps reduce pain and inflammation, it also disrupts the protective prostaglandins produced by COX-1. This disruption increases the risk of gastrointestinal side effects, such as ulcers and bleeding.<\/p>\n\n\n\n Celecoxib<\/strong>, as a selective COX-2 inhibitor, was developed to address this issue. By specifically targeting COX-2, celecoxib aims to reduce inflammation and pain while minimizing the gastrointestinal risks associated with nonselective COX inhibitors. Since it does not inhibit COX-1, it does not interfere with the production of prostaglandins that protect the stomach lining, leading to a lower risk of gastrointestinal toxicity compared to nonselective COX inhibitors.<\/p>\n\n\n\n Here\u2019s a brief look at why the other options are incorrect:<\/p>\n\n\n\n Thus, option A<\/strong> correctly highlights the benefit of celecoxib in terms of gastrointestinal safety.<\/p>\n","protected":false},"excerpt":{"rendered":" A nurse is teaching a client who has osteoarthritis and is prescribed celecoxib (Celebrex), a selective COX-2 inhibitor. What should the nurse include in the teaching? A. The drug has less gastrointestinal toxicity than nonselective COX inhibitors because it does not interfere with gastric mucosal protection by prostaglandins.B. The drug has more anti-inflammatory and analgesic […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[25],"tags":[],"class_list":["post-136851","post","type-post","status-publish","format-standard","hentry","category-exams-certification"],"_links":{"self":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/136851","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/comments?post=136851"}],"version-history":[{"count":0,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/136851\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/media?parent=136851"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/categories?post=136851"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/tags?post=136851"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Explanation<\/h3>\n\n\n\n
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