{"id":186270,"date":"2025-01-24T16:50:18","date_gmt":"2025-01-24T16:50:18","guid":{"rendered":"https:\/\/learnexams.com\/blog\/?p=186270"},"modified":"2025-01-24T16:50:22","modified_gmt":"2025-01-24T16:50:22","slug":"conceptual-checkpoint","status":"publish","type":"post","link":"https:\/\/www.learnexams.com\/blog\/2025\/01\/24\/conceptual-checkpoint\/","title":{"rendered":"Conceptual Checkpoint"},"content":{"rendered":"\n<p>Conceptual Checkpoint 07.41a Predict the major and minor products for the following reaction. OTS NaoEt ? Draw the major product. ? Edit Draw the minor product(s). ? Edit Conceptual Checkpoint 07.410 Predict the major and minor products for the following reaction. OTS NaSH ? Draw the major product. ? Edit Draw the minor product(s). ? Edit No minor products expected. Conceptual Checkpoint 07.41e Predict the major and minor products for the following reaction. HO ht 1) TSCI, py 2) t-BuOK ? Draw the major product. ? Edit Draw the minor product(s). ? Edit Conceptual Checkpoint 07.41f Predict the major and minor products for the following reaction. 1) TsCI, Py OH 2) NaOEt ? Draw the major product. ? Edit Draw the minor product(s). ? Edit<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/learnexams.com\/blog\/wp-content\/uploads\/2025\/01\/image-445.png\" alt=\"\" class=\"wp-image-186271\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/learnexams.com\/blog\/wp-content\/uploads\/2025\/01\/image-446.png\" alt=\"\" class=\"wp-image-186272\"\/><\/figure>\n\n\n\n<p><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ast-global-color-6-color\"><strong>The Correct Answer and Explanation is :<\/strong><\/mark><\/p>\n\n\n\n<p>In organic chemistry, predicting the major and minor products of reactions involves understanding the reactivity of functional groups and the influence of reagents and conditions. Let&#8217;s analyze the reactions provided:<\/p>\n\n\n\n<p><strong>1. Reaction: OTS + NaOEt<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reagents:<\/strong> Tosylate (OTs) and sodium ethoxide (NaOEt).<\/li>\n\n\n\n<li><strong>Mechanism:<\/strong> Sodium ethoxide, a strong nucleophile, will displace the tosyl group via an SN2 mechanism, resulting in the formation of an ether.<\/li>\n\n\n\n<li><strong>Major Product:<\/strong> The major product is the ether formed by the nucleophilic substitution of the tosyl group with the ethoxide ion.<\/li>\n\n\n\n<li><strong>Minor Products:<\/strong> No minor products are expected under these conditions.<\/li>\n<\/ul>\n\n\n\n<p><strong>2. Reaction: OTS + NaSH<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reagents:<\/strong> Tosylate (OTs) and sodium hydrosulfide (NaSH).<\/li>\n\n\n\n<li><strong>Mechanism:<\/strong> Sodium hydrosulfide, a strong nucleophile, will displace the tosyl group via an SN2 mechanism, leading to the formation of a thiol.<\/li>\n\n\n\n<li><strong>Major Product:<\/strong> The major product is the thiol formed by the nucleophilic substitution of the tosyl group with the hydrosulfide ion.<\/li>\n\n\n\n<li><strong>Minor Products:<\/strong> No minor products are expected under these conditions.<\/li>\n<\/ul>\n\n\n\n<p><strong>3. Reaction: HO\u2013 + TSCI, Py; then t-BuOK<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reagents:<\/strong> Hydroxide ion (HO\u2013), 2,4,6-triisopropylbenzenesulfonyl chloride (TSCI) in pyridine (Py), followed by tert-butoxide ion (t-BuOK).<\/li>\n\n\n\n<li><strong>Mechanism:<\/strong><\/li>\n\n\n\n<li><strong>Step 1:<\/strong> The hydroxide ion reacts with TSCI in pyridine to form a sulfonate ester, which is a good leaving group.<\/li>\n\n\n\n<li><strong>Step 2:<\/strong> The tert-butoxide ion, a strong base, abstracts a proton from the \u03b2-carbon of the sulfonate ester, leading to an elimination reaction (E2 mechanism) and the formation of an alkene.<\/li>\n\n\n\n<li><strong>Major Product:<\/strong> The major product is the alkene formed by the E2 elimination of the sulfonate ester.<\/li>\n\n\n\n<li><strong>Minor Products:<\/strong> No minor products are expected under these conditions.<\/li>\n<\/ul>\n\n\n\n<p><strong>4. Reaction: TsCl, Py; then NaOEt<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reagents:<\/strong> Tosyl chloride (TsCl) in pyridine (Py), followed by sodium ethoxide (NaOEt).<\/li>\n\n\n\n<li><strong>Mechanism:<\/strong><\/li>\n\n\n\n<li><strong>Step 1:<\/strong> The hydroxyl group (-OH) reacts with TsCl in pyridine to form a tosylate ester, enhancing the leaving group&#8217;s ability.<\/li>\n\n\n\n<li><strong>Step 2:<\/strong> Sodium ethoxide, a strong nucleophile, displaces the tosyl group via an SN2 mechanism, resulting in the formation of an ether.<\/li>\n\n\n\n<li><strong>Major Product:<\/strong> The major product is the ether formed by the nucleophilic substitution of the tosyl group with the ethoxide ion.<\/li>\n\n\n\n<li><strong>Minor Products:<\/strong> No minor products are expected under these conditions.<\/li>\n<\/ul>\n\n\n\n<p>In summary, each reaction involves a nucleophilic substitution or elimination mechanism, leading to the formation of the major product as indicated. No minor products are expected under the specified conditions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Conceptual Checkpoint 07.41a Predict the major and minor products for the following reaction. OTS NaoEt ? Draw the major product. ? Edit Draw the minor product(s). ? Edit Conceptual Checkpoint 07.410 Predict the major and minor products for the following reaction. OTS NaSH ? Draw the major product. ? Edit Draw the minor product(s). ? [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[25],"tags":[],"class_list":["post-186270","post","type-post","status-publish","format-standard","hentry","category-exams-certification"],"_links":{"self":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/186270","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/comments?post=186270"}],"version-history":[{"count":0,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/186270\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/media?parent=186270"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/categories?post=186270"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/tags?post=186270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}