{"id":204348,"date":"2025-03-21T18:34:39","date_gmt":"2025-03-21T18:34:39","guid":{"rendered":"https:\/\/learnexams.com\/blog\/?p=204348"},"modified":"2025-03-21T18:34:40","modified_gmt":"2025-03-21T18:34:40","slug":"does-the-net-gain-of-atp-in-glycolysis-differ-when-glycogen","status":"publish","type":"post","link":"https:\/\/www.learnexams.com\/blog\/2025\/03\/21\/does-the-net-gain-of-atp-in-glycolysis-differ-when-glycogen\/","title":{"rendered":"Does the net gain of ATP in glycolysis differ when glycogen"},"content":{"rendered":"\n<p>Does the net gain of ATP in glycolysis differ when glycogen, rather than glucose, is the starting material? If so, what is the change?<\/p>\n\n\n\n<p><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ast-global-color-6-color\"><strong>The correct answer and explanation is :<\/strong><\/mark><\/p>\n\n\n\n<p>Yes, the net gain of ATP in glycolysis differs when glycogen is the starting material instead of glucose.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Change in ATP Yield<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>When <strong>glucose<\/strong> is the starting material, <strong>2 ATP<\/strong> are consumed in the preparatory phase, but <strong>4 ATP<\/strong> are produced in the payoff phase, leading to a <strong>net gain of 2 ATP<\/strong>.<\/li>\n\n\n\n<li>When <strong>glycogen<\/strong> is the starting material, it is broken down into <strong>glucose-1-phosphate (G1P)<\/strong> by <strong>glycogen phosphorylase<\/strong>, which is then converted into <strong>glucose-6-phosphate (G6P)<\/strong> without consuming ATP.<\/li>\n\n\n\n<li>Normally, in glycolysis, glucose is phosphorylated to <strong>G6P<\/strong> by <strong>hexokinase<\/strong>, which <strong>consumes 1 ATP<\/strong>. However, since G6P is already formed from glycogen breakdown, this ATP cost is bypassed.<\/li>\n\n\n\n<li>This results in a <strong>net gain of 3 ATP<\/strong> instead of 2 ATP when starting from glycogen.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Explanation<\/strong><\/h3>\n\n\n\n<p>Glycogen is a stored polymer of glucose found mainly in the liver and muscles. During glycogenolysis, glycogen phosphorylase cleaves <strong>\u03b1-1,4-glycosidic bonds<\/strong> to release glucose-1-phosphate. Unlike free glucose, which requires ATP for phosphorylation by hexokinase, G1P is readily converted to G6P by phosphoglucomutase without ATP consumption.<\/p>\n\n\n\n<p>Once G6P enters glycolysis, it follows the standard pathway, producing 4 ATP in the payoff phase. Since no ATP was required for its initial phosphorylation, only <strong>one ATP (used in the phosphofructokinase-1 step)<\/strong> is subtracted from the total ATP yield. This leads to a net gain of <strong>3 ATP per glucose unit from glycogen<\/strong>, compared to <strong>2 ATP per free glucose molecule<\/strong>.<\/p>\n\n\n\n<p>This ATP advantage is particularly important in muscle cells during intense exercise, where rapid ATP production is crucial. The efficiency of ATP generation from glycogen makes it a preferred energy source in high-energy-demand situations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Does the net gain of ATP in glycolysis differ when glycogen, rather than glucose, is the starting material? If so, what is the change? The correct answer and explanation is : Yes, the net gain of ATP in glycolysis differs when glycogen is the starting material instead of glucose. Change in ATP Yield Explanation Glycogen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[25],"tags":[],"class_list":["post-204348","post","type-post","status-publish","format-standard","hentry","category-exams-certification"],"_links":{"self":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/204348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/comments?post=204348"}],"version-history":[{"count":0,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/204348\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/media?parent=204348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/categories?post=204348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/tags?post=204348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}