Fusion between a plasma cell and a tumor cell creates a<\/p>\n\n\n\n
a. Myeloma
b. Natural killer cell
c. Lymphoblast
d. Lymphoma
e. Hybridoma<\/p>\n\n\n\n
The correct answer and explanation is :<\/strong><\/mark><\/p>\n\n\n\n Correct Answer: e. Hybridoma<\/strong><\/p>\n\n\n\n A hybridoma<\/strong> is a cell line formed by the fusion of a plasma cell (B lymphocyte)<\/strong> with a tumor cell (usually a myeloma cell)<\/strong>. This fusion combines the desirable properties of both parent cells: the ability of the plasma cell to produce a specific antibody and the ability of the myeloma cell to proliferate indefinitely in culture. The result is a hybrid cell line<\/strong> that can continuously produce large quantities of a single type of antibody, known as a monoclonal antibody<\/strong>.<\/p>\n\n\n\n This technique was developed in the 1970s by Georges K\u00f6hler and C\u00e9sar Milstein<\/strong>, who were awarded the Nobel Prize for this work. The process involves isolating B cells from an immunized animal (usually a mouse) that is producing antibodies against a specific antigen. These B cells are then fused with immortal myeloma cells<\/strong> that have been modified so they cannot produce their own antibodies. The fusion is often facilitated using a chemical agent like polyethylene glycol (PEG).<\/p>\n\n\n\n After fusion, the hybrid cells are cultured in a selective medium, HAT medium (hypoxanthine-aminopterin-thymidine)<\/strong>, which allows only the successfully fused hybridomas to survive. Unfused myeloma cells die because they are deficient in an enzyme required to survive in HAT, and unfused B cells naturally die after a few days.<\/p>\n\n\n\n Each hybridoma cell line is capable of producing a single type of antibody\u2014making it monoclonal<\/strong>. These monoclonal antibodies have become indispensable tools in diagnostics, therapeutics (such as in cancer treatment or autoimmune diseases), and basic biomedical research due to their specificity.<\/p>\n\n\n\n Thus, option (e) Hybridoma<\/strong> is the correct answer as it specifically describes the fusion product of a plasma cell and a tumor cell.<\/p>\n\n\n\n Fusion between a plasma cell and a tumor cell creates a a. Myelomab. Natural killer cellc. Lymphoblastd. Lymphomae. Hybridoma The correct answer and explanation is : Correct Answer: e. Hybridoma A hybridoma is a cell line formed by the fusion of a plasma cell (B lymphocyte) with a tumor cell (usually a myeloma cell). This […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[25],"tags":[],"class_list":["post-210212","post","type-post","status-publish","format-standard","hentry","category-exams-certification"],"_links":{"self":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/210212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/comments?post=210212"}],"version-history":[{"count":0,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/210212\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/media?parent=210212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/categories?post=210212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/tags?post=210212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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