{"id":233949,"date":"2025-06-13T15:08:35","date_gmt":"2025-06-13T15:08:35","guid":{"rendered":"https:\/\/learnexams.com\/blog\/?p=233949"},"modified":"2025-06-13T15:08:37","modified_gmt":"2025-06-13T15:08:37","slug":"which-of-the-following-statements-about-collagen-is-false","status":"publish","type":"post","link":"https:\/\/www.learnexams.com\/blog\/2025\/06\/13\/which-of-the-following-statements-about-collagen-is-false\/","title":{"rendered":"Which of the following statements about collagen is false"},"content":{"rendered":"\n<p>Which of the following statements about collagen is false? The collagen proteinase cleaves the termini of pro collagen. Cells bind collagen directly through cell surface integrin proteins. Single collagen polypeptide chains are assembled into triple stranded helices. Which of the following is a function of gap junctions? To adhere cells to one another through adherin proteins. To allow the passage of ions between cells. To prevent the lateral diffusion of proteins and lipids. To adhere cells to the basal lamina. The transmembrane integrin proteins can be found in which of the following types of adhesion junctions? A) Tight junctions. B) Adherens junctions. C) Hemidesmosomes. D) Desmosomes. Which of the following is not true of the basal lamina? A) It is a structure upon which epithelial cells rest. B) It contains osteoblasts. C) It is composed of collagen and laminin. D) Epithelial cells attach to it through hemidesmosomes.<\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ast-global-color-1-color\">The Correct Answer and Explanation is:<\/mark><\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Correct Answers:<\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>False statement about collagen:<\/strong><br><strong>Cells bind collagen directly through cell surface integrin proteins.<\/strong> \u2190 <strong>False<\/strong><\/li>\n\n\n\n<li><strong>Function of gap junctions:<\/strong><br><strong>To allow the passage of ions between cells.<\/strong><\/li>\n\n\n\n<li><strong>Integrins are found in:<\/strong><br><strong>C) Hemidesmosomes<\/strong><\/li>\n\n\n\n<li><strong>Not true of the basal lamina:<\/strong><br><strong>B) It contains osteoblasts.<\/strong><\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Detailed Explanation:<\/h3>\n\n\n\n<p><strong>1. Collagen \u2013 False Statement<\/strong><br>The incorrect statement is: <em>\u201cCells bind collagen directly through cell surface integrin proteins.\u201d<\/em><br>This is false because integrins do not bind directly to collagen. Instead, they usually bind to collagen indirectly through bridging molecules like <strong>fibronectin<\/strong>. Fibronectin binds to collagen and also contains a binding site for integrins, forming a connection between the extracellular matrix and the cytoskeleton inside the cell. Collagen proteinase does cleave the N- and C-terminal ends of procollagen, and three collagen polypeptide chains form a stable triple-stranded helix, both of which are true.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>2. Gap Junction Function<\/strong><br>Gap junctions are specialized intercellular connections that form channels allowing the <strong>passage of ions and small molecules<\/strong> between adjacent cells. This communication is essential in many tissues, such as cardiac muscle, where ion movement coordinates muscle contraction. Gap junctions are <strong>not involved in adhesion<\/strong>, <strong>blocking diffusion<\/strong>, or <strong>basal lamina attachment<\/strong>\u2014those are roles of other junction types like <strong>tight junctions<\/strong>, <strong>adherens junctions<\/strong>, or <strong>hemidesmosomes<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>3. Integrins in Adhesion Junctions<\/strong><br>Integrins are <strong>transmembrane receptor proteins<\/strong> that mediate the attachment of a cell to the extracellular matrix, particularly in <strong>hemidesmosomes<\/strong>. Hemidesmosomes connect the basal surface of epithelial cells to the basal lamina. Tight junctions and desmosomes do not involve integrins; instead, they use other adhesion molecules such as claudins, occludins, and cadherins.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>4. Basal Lamina \u2013 False Statement<\/strong><br>The statement <em>\u201cIt contains osteoblasts\u201d<\/em> is false. The basal lamina is a specialized sheet of the extracellular matrix composed primarily of <strong>collagen (especially type IV)<\/strong> and <strong>laminin<\/strong>, and it supports <strong>epithelial cells<\/strong>, separating them from the underlying connective tissue. Osteoblasts are <strong>bone-forming cells<\/strong> found in bone tissue, not in the basal lamina.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/learnexams.com\/blog\/wp-content\/uploads\/2025\/06\/learnexams-banner8-372.jpeg\" alt=\"\" class=\"wp-image-233950\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Which of the following statements about collagen is false? The collagen proteinase cleaves the termini of pro collagen. Cells bind collagen directly through cell surface integrin proteins. Single collagen polypeptide chains are assembled into triple stranded helices. Which of the following is a function of gap junctions? To adhere cells to one another through adherin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[25],"tags":[],"class_list":["post-233949","post","type-post","status-publish","format-standard","hentry","category-exams-certification"],"_links":{"self":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/233949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/comments?post=233949"}],"version-history":[{"count":0,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/233949\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/media?parent=233949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/categories?post=233949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/tags?post=233949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}