{"id":244271,"date":"2025-07-05T02:49:20","date_gmt":"2025-07-05T02:49:20","guid":{"rendered":"https:\/\/learnexams.com\/blog\/?p=244271"},"modified":"2025-07-05T02:49:22","modified_gmt":"2025-07-05T02:49:22","slug":"chemistry-the-two-amino-acids-having-r-groups-with-a-negative-net-charge-at-ph-7-0-are-cysteine-and-methionine-aspartate-and-glutamate-proline-and-valine-arginine-and-histidine-next","status":"publish","type":"post","link":"https:\/\/www.learnexams.com\/blog\/2025\/07\/05\/chemistry-the-two-amino-acids-having-r-groups-with-a-negative-net-charge-at-ph-7-0-are-cysteine-and-methionine-aspartate-and-glutamate-proline-and-valine-arginine-and-histidine-next\/","title":{"rendered":"CHEMISTRY The two amino acids having R groups with a negative net charge at pH 7.0 are Cysteine and methionine Aspartate and glutamate Proline and valine Arginine and histidine Next"},"content":{"rendered":"\n<p>CHEMISTRY The two amino acids having R groups with a negative net charge at pH 7.0 are Cysteine and methionine Aspartate and glutamate Proline and valine Arginine and histidine Next This form was created inside of University of Babylon: Report Abuse Google Forms<\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-ast-global-color-0-color\">The Correct Answer and Explanation is:<\/mark><\/strong><\/p>\n\n\n\n<p>The correct answer is <strong>Aspartate and glutamate<\/strong>.<\/p>\n\n\n\n<p>Explanation:<\/p>\n\n\n\n<p>At physiological pH (around 7.0), amino acids with side chains that can lose a proton (become negatively charged) typically have acidic functional groups. These side chains are known to have a <strong>negative net charge<\/strong> at this pH.<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Aspartate (Asp)<\/strong> and <strong>glutamate (Glu)<\/strong> are the two amino acids with carboxylate groups (-COO\u207b) in their side chains. The carboxyl group can dissociate, losing a proton (H\u207a) and thereby carrying a negative charge at physiological pH (pH 7.0). This makes both of these amino acids negatively charged at this pH.<\/li>\n\n\n\n<li><strong>Cysteine<\/strong> and <strong>methionine<\/strong> do not have acidic side chains; cysteine has a thiol group (-SH), which does not ionize significantly at pH 7.0. Methionine has a non-polar side chain and thus does not carry a charge at physiological pH.<\/li>\n\n\n\n<li><strong>Proline<\/strong> and <strong>valine<\/strong> both have non-polar side chains and do not have acidic or basic groups that can gain or lose protons. Therefore, they do not have a net negative charge at pH 7.0.<\/li>\n\n\n\n<li><strong>Arginine<\/strong> and <strong>histidine<\/strong> have positively charged side chains (due to the presence of amino groups in their side chains), so they would have a positive net charge at physiological pH, not a negative one.<\/li>\n<\/ol>\n\n\n\n<p>Thus, <strong>aspartate<\/strong> and <strong>glutamate<\/strong> are the amino acids that have R groups with a negative net charge at pH 7.0.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/learnexams.com\/blog\/wp-content\/uploads\/2025\/07\/learnexams-banner5-416.jpeg\" alt=\"\" class=\"wp-image-244272\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>CHEMISTRY The two amino acids having R groups with a negative net charge at pH 7.0 are Cysteine and methionine Aspartate and glutamate Proline and valine Arginine and histidine Next This form was created inside of University of Babylon: Report Abuse Google Forms The Correct Answer and Explanation is: The correct answer is Aspartate and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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