Polymyxin B <\/p>\n\n\n\n
a. Drug class: <\/p>\n\n\n\n
b. Uses\/condition treated <\/p>\n\n\n\n
c. Side effects: <\/p>\n\n\n\n
d. Contraindications: <\/p>\n\n\n\n
e. Routes of administration:<\/p>\n\n\n\n
The correct answer and explanation is:<\/mark><\/strong><\/p>\n\n\n\n Polymyxin B<\/strong><\/p>\n\n\n\n a. Drug Class<\/strong>: b. Uses\/Condition Treated<\/strong>: c. Side Effects<\/strong>: d. Contraindications<\/strong>: e. Routes of Administration<\/strong>: Polymyxin B remains an important agent against multidrug-resistant bacteria, but its use is restricted due to its potential toxicity.<\/p>\n","protected":false},"excerpt":{"rendered":" Polymyxin B a. Drug class: b. Uses\/condition treated c. Side effects: d. Contraindications: e. Routes of administration: The correct answer and explanation is: Polymyxin B a. Drug Class:Polymyxin B belongs to the class of polymyxins, which are antibiotics that work by disrupting the bacterial cell membrane. Specifically, it is a cyclic peptide antibiotic. b. Uses\/Condition […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[25],"tags":[],"class_list":["post-260502","post","type-post","status-publish","format-standard","hentry","category-exams-certification"],"_links":{"self":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/260502","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/comments?post=260502"}],"version-history":[{"count":0,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/posts\/260502\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/media?parent=260502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/categories?post=260502"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.learnexams.com\/blog\/wp-json\/wp\/v2\/tags?post=260502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Polymyxin B belongs to the class of polymyxins<\/strong>, which are antibiotics that work by disrupting the bacterial cell membrane. Specifically, it is a cyclic peptide antibiotic<\/strong>.<\/p>\n\n\n\n
Polymyxin B is used primarily to treat infections caused by gram-negative bacteria<\/strong>, especially Pseudomonas aeruginosa<\/strong>, Escherichia coli<\/strong>, Klebsiella species<\/strong>, and Enterobacter species<\/strong>. It is typically employed for infections in wounds, burns, eyes<\/strong>, and the urinary tract<\/strong>, as well as systemic infections<\/strong> in more severe cases. It can also be used as part of a combination therapy in multidrug-resistant infections<\/strong>.<\/p>\n\n\n\n
While effective, Polymyxin B has notable side effects. Common side effects include nephrotoxicity<\/strong> (kidney damage), especially with prolonged use or in patients with existing kidney problems. Neurotoxicity<\/strong> is another concern, causing symptoms such as numbness, tingling, dizziness<\/strong>, and in severe cases, seizures<\/strong>. Other side effects can include allergic reactions<\/strong> like skin rash, pruritus (itching), and fever<\/strong>. Respiratory distress<\/strong> can also occur in some cases, particularly if the drug is administered intravenously or via inhalation.<\/p>\n\n\n\n
Polymyxin B is contraindicated in individuals with known hypersensitivity<\/strong> to polymyxins. It should be used cautiously in those with pre-existing kidney disorders<\/strong>, as it may exacerbate renal toxicity. It should be avoided in pregnant women<\/strong> unless absolutely necessary, as it falls under category C<\/strong> for pregnancy, meaning there is a potential risk to the fetus.<\/p>\n\n\n\n
Polymyxin B can be administered via several routes depending on the nature and severity of the infection. The intravenous route<\/strong> is often used for systemic infections. It is also available as topical ointments<\/strong> (used for eye and skin infections) and as inhalation therapy<\/strong> for respiratory infections. For urinary tract infections<\/strong>, it may be instilled directly into the bladder.<\/p>\n\n\n\n