ABGC final review Errorless Answers

ABGC final review ( Errorless Answers)
Gail Model Pros Lifetime and 5-year breast cancer risk
Determine eligibility to take chemoprevention
Includes age, age at first live birth, age at menarche, # of FDR with BC, breast biopsy, atypical hyperplasia, race
Gail model cons NOT used for women with LCIS/DCIS
No other cancers
Does not consider SDR
Does not consider paternal history
Does not consider age of onset for cancers
Underestimates risk
Claus Tables Calculate BC risk based on family history of breast cancer only
Breast cancer prior probability models BRCAPro
Penn II
BOADICEA
Tyler-Cuzick
Myriad
High penetrance breast cancer genes BRCA1: 20-30%
BRCA2: 10-20%