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1. A patient has been prescribed a medication that undergoes
extensive hepatic metabolism. Which of the following enzymes
primarily facilitates this metabolism?
A) CYP2D6
B) CYP3A4
C) CYP2C9
D) CYP1A2
Answer: B) CYP3A4
Rationale: CYP3A4 is the major enzyme responsible for
metabolizing a significant number of drugs through hepatic
metabolism. This enzyme plays a crucial role in drug interactions
and variability in drug response.
2. Which of the following pharmacokinetic parameters is used to
determine the time it takes for the drug concentration to decrease
by half in the body?
A) Bioavailability
B) Half-life
C) Clearance
D) Volume of distribution
Answer: B) Half-life
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