Antidiabetic Medications Overview Exam Review Solution

Antidiabetic Medications Overview Exam Review Solution
Xanthine Oxidase Inhibitors - ANS-Medications like colchicine, allopurinol, and febuxostat used to treat
gout
Colchicine Dosing - ANS-Initial dose of 1.2 mg at first sign of flare, then 0.6 mg 1 hour later (MAX: 1.8
mg/hour)
Colchicine Side Effects - ANS-Diarrhea, malabsorption of B12, hepatotoxicity, renal stone development,
myopathy, neuropathy
Allopurinol Usage - ANS-Prophylactic treatment of gout, not for acute flares
Steroids Mechanism - ANS-Inhibits arachidonic acid metabolism, stabilizes biologic membranes, impairs
phagocytosis, lymphocytes, and tissue repair
Steroids GI Side Effects - ANS-GI bleeding, peptic ulcer disease, ulcerative colitis, nephrotic syndrome,
hepatic disease
Steroids Skin Side Effects - ANS-Thinning of skin, alopecia, acne, purpura, striae, hirsutism, muscle
wasting
Steroids Skeletal Side Effects - ANS-Osteoporosis, skeletal fractures; treated with alendronate or
risedronate
Steroids Ocular Side Effects - ANS-Subcapsular cataracts, glaucoma, optic nerve damage
NSAIDs Black Box Warning - ANS-GI bleed, ulceration, cardiovascular events (MI, stroke)