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1. What is drug distribution and why is it an important factor in
pharmacokinetics?
- Answer: Drug distribution refers to the process by which a drug is
transported throughout the body. It is vital for achieving therapeutic
effects and understanding drug metabolism. The drug distribution process
determines how a drug is delivered to target tissues and organs.
2. Explain the term ‘plasma protein binding’ and its significance in drug
distribution.
- Answer: Plasma protein binding refers to the attachment of drugs to
plasma proteins, predominantly albumin. This binding affects the drug's
distribution and availability for action. Drugs bound to proteins have a
longer half-life and slower elimination, while unbound drugs are more
pharmacologically active.
3. How does drug distribution differ between highly lipophilic and highly
hydrophilic drugs?
- Answer: Highly lipophilic drugs easily penetrate cell membranes and
distribute extensively into tissues, leading to a larger volume of
distribution. On the other hand, highly hydrophilic drugs tend to remain in
the plasma rather than entering tissues, resulting in a smaller volume of
distribution.
4. Discuss the concept of blood-brain barrier and its impact on drug
distribution to the central nervous system.
- Answer: The blood-brain barrier acts as a protective mechanism,
preventing many drugs from freely entering the brain. Only drugs withÂ
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