BMTCN Medication

BMTCN Medication
ATG Immune Suppressant.
not recommended for reduced intensity regimens
s/s pulm edema, hepatic dysfunction.
Skin rash, joint pains(serum Sickness-TREATED WITH STEROIDS)
Used before Allo for immunosuppression and later to treat GVHD.
BCNU(carmustine)
✓ ✓ nephro toxic
pulm toxic-cough, dyspnea,
Busulfan✓
✓ neurotoxic SEIZURE-use levetiracetam
hepatitis, VOD,
rash, hairloss may be permanent
pulmonary fibrosis
premenopausal ovarian suppression
Cyclophosphamide ✓ ✓ MESNA and hydration can be used to prevent
HEMORRAGIC CYSTITIS.
CARDIO TOXIC-
SIADH-hyponatremia and seizures.-free water restriction(furosimide) pulmonary toxic.
Etoposide-✓✓ anaphylaxis
Gl toxic
plantr and palmar burning
CARDIO TOXIC PERIPHERAL NEUROPATHY