BMTCN Review Chapter 2-Types of Transplants and Sources of Stem Cells

BMTCN Review Chapter 2-Types of Transplants and Sources of Stem Cells
-Allogeneic
-Syngeneic
-Autologous -
'Types of SCT (3)
-Peripheral Blood (PBSCT)
-Bone Marrow
-Umbilical Cord (UCB)
✓ ✓ Stem Cell Sources (3)
-Syngeneic
-Matched sibling/related
-Mismatch related
-Matched unrelated
-Mismatched unrelated
-Umbilical cord✓
✓ Specific Types of Allogeneic Transplant (6)
-Identical twin
-No need for immunosuppression, disease free source
-No graft vs tumor effect ✓
✓ Syngeneic
(source, advantages, disadvantages)
-HLA matching, non self
-Disease free stem cell source, Potential for graft versus tumor effect
-Graft-versus-host-disease (GVHD), Substantial morbidity and mortality, Donor procurement,
Immunosuppressive medication
✓ ✓ Allogeneic