Camilla Franklin Ihuman Week #10: A 48-Year-Old Female with Fatigue and Irritability Case Study

Camilla Franklin Ihuman Week #10: A 48-Year-Old Female with Fatigue and Irritability Case Study
Most common finding of Metabolic
Syndrome
Insulin resistance!
(associated with inflammatory state)
Pathophysiology of insulin resistance
1. Upregulation of insulin receptor
inhibitors
-Ex: insulin-like growth factor (IGF)-1
receptor
2. GLUT-4 disruption
-Normally carries glucose into the cells,
stimulated by insulin and exercise
-Causes inc. bl. glucose
Insulin resistance: skeletal muscles
Reduced glucose disposal from the blood
stream
Insulin resistance: liver
Increased glucose production
Insulin resistance: pancreatic beta cells
Impaired insulin secretion
Hallmark of insulin resistance
Lipotoxicity!
-Build up of fat in the muscles, liver, and
plasma
Metabolic Syndrome risk factors
Demographic: women, Hispanics, advancing
age
Metabolic: elevated fasting glucose levels,
elevated triglycerides, reduced HDL,
hypertension, central obesity (apple or pear
shaped), Nonalcoholic Fatty Liver Disease
Environmental: Bisphenol A (BPA--found in
plastic), persistent organic pollutants (POPs)
Nonalcoholic Fatty Liver Disease
Hepatic accumulation of >5% liver weight.

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