CMN 554- Unit 3 Review Test.

CMN 554- Unit 3 Review Test.

-Major neurotransmitters involved in developing substance
abuse/dependence: opioid, catecholamine (particularly
dopamine), GABA
-Dopaminergic neurons in the ventral tegmental area project to
the cortical and limbic regions, especially the nucleus
accumbens.
-This pathway probably involved in sensation of reward
-May be major mediator of the effects of substances
(amphetamine & cocaine)
-Locus ceruleus mediates effects of opiates and the opioids
-These pathways collectively called the brain-reward circuitry
Question 1: What is the reward pathway involved in substance
abuse?
CORRECT ANSWER: Dopaminergic neurons in the ventral
tegmental area project to the cortical and limbic regions,
especially the nucleus accumbens.

In some Asian persons, the decreased function of alcohol-
metabolizing enzymes can also lead to easy intoxication and

toxic symptoms.

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