D116 NURS 6800 Advanced Pharmacology FINAL ASSESSMENT READINESS QUESTIONS & ANSWERS

D116 NURS 6800 Advanced Pharmacology FINAL ASSESSMENT READINESS QUESTIONS & ANSWERS
1. Which CYP450 enzyme is primarily responsible for the
metabolism of warfarin, and how does it affect dosing?
 - A) CYP2D6
 - B) CYP2A6
 - C) CYP3A4
 - D) CYP2C9
 - Answer: D) CYP2C9
 - Rationale: Warfarin is mainly metabolized by CYP2C9,
and variations in this enzyme can significantly affect drug
clearance and necessitate dosage adjustments.
2. In treating hypertension, ACE inhibitors are often
prescribed. What is the primary mechanism by which these
drugs lower blood pressure?
 - A) Reducing heart rate
 - B) Blocking angiotensin II formation
 - C) Increasing sodium retention
 - D) Enhancing vasoconstriction
 - Answer: B) Blocking angiotensin II formation
 - Rationale: ACE inhibitors prevent the conversion of
angiotensin I to angiotensin II, leading to vasodilation and
decreased blood pressure.
3. Which of the following medications is a biologic response
modifier used in chronic inflammatory diseases like
rheumatoid arthritis?
 - A) Methotrexate
 - B) Levodopa
 - C) Adalimumab
 - D) Metformin
 - Answer: C) Adalimumab
 - Rationale: Adalimumab is a monoclonal antibody that