FREE PHARMACOLOGY AND STUDY GAMES ABOUT

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FREE PHARMACOLOGY AND STUDY GAMES ABOUT

NAPLEX EXAM QUESTIONS

Actual Qs and Ans Expert-Verified Explanation

This Exam contains:

-Guarantee passing score -74 Questions and Answers -format set of multiple-choice -Expert-Verified Explanation

Question 1: clearance equation

Answer:

rate of elimination/ concentration

Question 2: Azathioprine- pharmacogenomics

Answer:

TPMT- low/absent activity = increased risk of myelosuppression

Question 3: avoid these with drugs that have increased bleed risk

Answer:

NSAIDs, SSRIs/SNRIs, ginko biloba, garlic, ginger, glucosamine, ginseng

Question 4: Specificity

Answer:

1- type I error (false positive)

Question 5: Statins- drug interactions

Answer:

increased levels = increased muscle toxicity

-most are CYP3A4 metabolites: atorvastatin, simvastatin, lovastatin

Question 6: Corrected calcium

Answer:

Calcium reported (serum) + [(4-albumin)(0.8)]

Question 7: CYP450 enzyme inhibitors "BIGFACES.COM"

Answer:

"BIGFACES.COM" Bupropion Itraconazole/ketoconazole/fluoxetine Gemfibrozil Fluoxetine/fluvoxamine Amiodarone Ciprofloxacin Erythromycin/Clarithromycin Sulfamethoxazole-trimethoprim Clopidogrel Omeprazole/Esomeprazole Metronidazole

Question 8: Digoxin- drug interactions

Answer:

-increase in levels: likely due to decreased renal function

-toxicity more likely if potassium low -P-gp substrate, narrow therapeutic range -caution with drugs that lower INR: beta blockers, non-dhp CCBs, amiodarone, dexmedetonidine (Precidex), clonidine, opioids

Question 9: Calcium conversions

Answer:

Carbonate: 40% elemental calcium

Citrate: 21% elemental calcium

Question 10: Codeine- pharmacogenomics

Answer:

consider testing CYP450 2D6 -ultrametablizers = toxicity risk

Question 11: % ionization of weak base

Answer:

100/1 + 10^(pH-pKa)

Question 12: % ionization of a weak acid

Answer:

100/1 + 10^(pKa-pH)

Question 13: 1 gallon

Answer:

• quarts

3840 mL (approx) 3785 mL (exact)

Question 14: Cl renal > Cl GFR

Answer:

filtration + net secretion

Question 15: drugs that cause TTP

Answer:

clopidogrel, ticlopidine

Question 16: Tramadol- drug interactions

Answer:

-2D6 metabolized to active form -diministed effect on 2D6 inhibitors (fluoxetine, paroxetine, or poor metabolizers of 2D6)

Question 17: 1 fluid oz

Answer:

30 mL (approx) 29.57 mL (exact)

Question 18: absolute risk reduction

Answer:

%risk in control - % risk in treatment group

Question 19: When calculating CrCl- which body weight to use?

Answer:

Underweight: TBW

Normal: IBW

Overweight/obese: AdjBW

Question 20: Drugs that cause severe skin reactions

Answer:

allopurinol, lamotrigine, penicillins, phenytoin, piroxicam, sulfamethoxazole

Question 21: Carbamazepine- pharmacogenomics

Answer:

HLA-*1502

-test in Asian populations- increased risk of serious skin reactions

Question 22: Amiodarone- drug interactions

Answer:

-Digoxin -Warfain =decrease dose of digoxin or warfarin by 30-50% when starting amiodarone

Question 23: Quinolones, tetracyclines- drug interactions

Answer:

Chelation risk, seperate from vitamins, electrolytes

Question 24: Relative risk reduction

Answer:

1- RR or (%risk in control- % risk in treatment)/ % risk in control