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Chapter 1: Pharmacokinetics and Routes of Administration
ï‚· Absorption
 Route of admin affects the rate and amount of absorption
o Oral:
 GI pH and emptying time
 Presence of food in the stomach or intestines
 Form of meds (liquid/XR)
o Sublingual/buccal
 Quick absorption systemically through highly vascular mucous membranes
o Inhalation via mouth/nose
 Rapid absorption through alveolar capillary networks
o Intradermal, topical
 Slow, gradual absorption
o SQ/IM
 Highly soluble meds have rapid absorption (10-30min), poorly soluble have
slower absorption
 Blood perfusion at site of injection affect absorption
o IV
ï‚· Distribution
 Immediate and complete
o Transportation of medsto sites of action by body fluids
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