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Neurotransmitter Table
* To be completed throughout course and submitted in Week 8*
Neuro
transmitter
Receptor
Subtype
Location/Function/Effects
/symptoms of excess or
deficit if applicable
Distribution
(ie: CNS/PNS,
GI, vascular)
Drug classes that
target this
neurotransmitter or
receptor
Specific medicationsthat target this
neurotransmitter or receptor
Glutamate AMPA α-Amino-3-hydroxy-5-
methyl-4-
isoxazolepropionic acid
(AMPA)-type glutamate
receptors (AMPARs)
mediate the majority of
fast excitatory synaptic
transmission in the brain.
AMPA receptors are
abundant and widely
distributed in the central
nervous system.
Hippocampus, outer layer
of the cortex, basal
ganglia, olfactory regions,
lateral septum, and
amygdala of the CNS are
all enriched with GluA1,
GluA2, and GluA3
subunits.
CNS AMPA Receptor
Antagonists
Perampanel
MNDA N-methyl-D-aspartate
(NMDA) receptors
represent one of the
ligand-gated non-selective
ionotropic glutamate
receptors(iGluRs), which
CNS
NMDA receptors
are found in
both synaptic
and
extrasynaptic
NDMA Glutamate
Antagonist
NDMA Glutamate Antagonist-
Memantine
Phencyclidine
Ketamine
Dextromethorphan
Dextromethadone
are present in high density
within the hippocampus
and the cerebral cortex
N-methyl-D-aspartate
(NMDA) receptors, a
family of L-glutamate
receptors, play an
important role in learning
and memory, and are
critical forspatial memory
demonstrated
deterioration in NMDA
receptor subunit
expression and function
with advancing age
locations on
neurons. NMDA
receptors also
can be found on
neurons in early
stages prior to
synaptogenesis,
where they may
be involved in
migration and
differentiation.
Extrasynaptic
NMDA receptors
typically are
associated with
contacts with
adjacent
processes such
as axons and
glia
GABA GABA a Limbic system
GABAa is considered in
fastsynaptic inhibition.
GABAa
receptors are
located
throughout the
central nervous
system
Benzodiazepines
Neuroactive Steroids
Zolpidem
Zaleplon
Zopiclone
Eszopiclone
Allepregnanolone
Serotonin
5HT
5HT 1a 5HT1A receptors are
located on GABA
interneurons in the
prefrontal cortex
5HT1A receptors can
promote the release of
CNS partial 5-HT1A-R
agonists
buspirone, gepirone, and
tandospirone
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