NSG3022 Pharmacotherapeutics I FINAL EXAM REVIEW QUESTIONS & ANSWERS

NSG3022 Pharmacotherapeutics I FINAL EXAM REVIEW QUESTIONS & ANSWERS

1. Which of the following factors most significantly influences the
pharmacokinetics of a drug in elderly patients?
 - A) Renal function
 - B) Age
 - C) Body weight
 - D) Gender
 Answer: A) Renal function
 Rationale: Renal function decline is a common change in elderly
patients, affecting drug clearance and thereby influencing
pharmacokinetics.
2. A patient is prescribed a drug that is a CYP3A4 substrate.
Which agent should be avoided to prevent increased drug levels?
 - A) Grapefruit juice
 - B) Omeprazole
 - C) Acetaminophen
 - D) Metformin
 Answer: A) Grapefruit juice
 Rationale: Grapefruit juice inhibits CYP3A4, leading to
increased levels of drugs that are metabolized by this enzyme.

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