NUR 325 Diabetes Drugs

NUR 325 Diabetes Drugs
1. what is the prototype for sulfonylureas?
Answer
glipizide (Glucotrol)
2. what is the pharmacologic action of sulfonylureas?
Answer
- stimulates release of insulin from beta cells of the pancreas
- will lower blood glucose levels whether high or low
3. which generation of Sulfonylureas is more potent with fewer drug interactions?
Answer
2nd Gen
4. what are the pharmacokinetics of sulfonylureas?
Answer
- liver metabolism
- urine excretion
5. what is the administration of sulfonylureas?
Answer
30 mins before meals, some- times split dose BID
6. what are you monitoring in sulfonylureas?
Answer
- intermittent glucose levels
- LFTs, BUN, Cr at baseline
- If over 65, continue to monitor BUN and Cr