NURS 6521 ADVANCED PHARMACOLOGY

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NURS 6521 ADVANCED PHARMACOLOGY

EXAM (FULL TEST) || 2025 ACTUAL EXAM ALL

QUESTIONS AND 100% CORRECT ANSWERS

GRADE A+|| LATEST AND COMPLETE UPDATED

VERSION 2025|| GUARANTEED PASS!!!

Which of the following statements about pharmacodynamic phase is correct?Pharmacodynamic phase studies the amount of drug that is excreted into breast milk.

Pharmacodynamic phase is related to the drug-receptor interaction and its biological effect. ###

Optimization of the pharmacodynamic phase improves drug bioavailability.

Pharmacodynamic phase is concerned with the amount of drug that is metabolized by the liver.

Pharmacodynamic phase is concerned with drug absorption.

If a patient starts taking Drug A with a Kd of 100 nM (nanomolar) and then switches to Drug B with a Kd of 100 µM (micromolar), and both drugs target the same receptor, which of the following statements is true? More people in a population will respond to Drug A than to Drug B.

Drug B has higher efficacy.

The toxicity of Drug A is much higher than the toxicity of Drug B.

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The binding affinity of Drug A is much higher than the binding affinity of Drug B.###

The binding affinities of the two drugs are not different.

What best describes EC50? The effective concentration of a drug produces 50% of the maximal effect. ###

The dose required to achieve 50% mortality from toxicity.

The dose that is required to achieve 50% of the desired response in 50% of the population.

The effective concentration of a drug that produces 50% of the minimum effect.

The dose required to get 50% of the population reporting toxic side effects.

A patient is being treated for depression with a specific medication. The pharmacokinetic profile of this medication reveals a dissociation constant (Kd) of 344 pg/mL and an effective dose for 50% of the population (ED50) of 200 pg/mL.What can be inferred from these pharmacokinetic parameters? The drug requires full receptor saturation to be effective, as indicated by the Kd and ED50 values.

The presence of spare receptors can be inferred from these values. ###

An ED50 lower than Kd suggests the drug is ineffective.

The medication is likely to cause severe side effects due to high potency.

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The drug's high Kd value indicates it has a very high binding affinity.

How does the lipophilicity of a drug affect its efficacy? A lower lipophilicity leads to a higher rate of desorption into the food.

A higher lipophilicity leads to a higher membrane permeability and metabolic clearance of the drug. ###

A higher lipophilicity leads to a lower metabolic clearance of the drug.

A higher lipophilicity leads to a lower membrane permeability of the drug.

A lower lipophilicity leads to a higher rate of absorption into the circulatory system.

Which of the following statements is NOT true? The phosphate group in the molecular structure of "Fosamprenavir" enhances the aqueous solubility and greater bioavailability during anti-viral therapy.

If given in its unaltered form as an oral medication, tetracycline will effectively interfere with the protein biosynthesis process in eukaryotic cells. ###

The introduction of a polar group reduces the lipophilicity of the drug and renders it less prone to metabolism.

The conversion of tetracycline into chlortetracycline leads to enhanced absorption and bioavailability.

Enzymes like esterase or phosphatase play a significant role in the conversion of a prodrug into an active form.

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Which receptor type typically functions using cAMP as a mediator?Transmembrane protein

Ion channel

Tyrosine kinase receptor

G-protein coupled receptor ###

Steroid receptor

What is the definition of pharmacodynamics? The movement of a drug through the body

Strength of attraction of a medication to a cell

The biggest effect of a medication

The effect of drugs on the body

In pharmacodynamics, what term is defined as the biggest effect that a medication can have in the body? Maximal efficacy ###

Affinity

Potent drug