PAS 535 Hepatobiliary Patho Exam

PAS 535 Hepatobiliary Patho Exam
What does Hgb break down into?
unconjugated (indirect) bilirubin
Heme breaks down into:
biliverdin --> bilirubin
What type of bilirubin is toxic and lipid soluble?
unconjugated (indirect) bilirubin
What does unconjugated (indirect) bilirubin bind to?
Albumbin
Where does UCB bound to albumin travel?
Liver
Where is bilirubin conjugated?
Liver
What is bilirubin conjugated with?
glucuronic acid via the enzyme UDP glucuronyl transferase
What type of bilirubin is water soluble?
conjugated (direct) bilirubin
What type of bilirubin is excreted in urine and secreted into bile?
conjugated (direct) bilirubin
What is conjugated (direct) bilirubin converted to in the intestines?
Urobilinogen
Urobilinogen eventually becomes:
Feces
What is the result of hyperbilirubinemia?
Jaundice
Why does jaundice occur in the sclera first?
bilirubin has affinity for elastin
Jaundice typically occurs with a serum bili:

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