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PAS 648 Constipation, Diarrhea, IBS and IBD Exam

Study Material Jul 15, 2025
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PAS 648 Constipation, Diarrhea, IBS and IBD Exam
What is in rehydration therapy for diarrhea?
glucose, water and balance of electrolytes (Na+, K+, HCO3-)
What is preferred rehydration therapy?
Oral rehydration solution (ORS)
What is the MOA of opiates?
delay transit time, increase gut capacity
What are the opiates for diarrhea?
- Loperamide peripheral acting opiate (OTC)
- Diphenoxylate (Rx) +atropine (LOMITIL)
What are indications for opiates?
- acute and chronic diarrhea not due to severe inflammatory infections
- May be used for traveler's diarrhea
What are the AE of opiates?
- dizziness and constipation
- Dry mouth, constipation, blurry vision w/ atropine
When should opiates be avoided in diarrhea?
fever and /or severe bloody diarrhea
What is the antisecretory agent used for diarrhea?
Bismuth subsalicylate (PeptoBismal)
What is the MOA of Bismuth subsalicylate (PeptoBismal)?
Antisecretory, anti-inflammatory and antibacterial effects
What is the indication for Bismuth subsalicylate (PeptoBismal)?
traveler's diarrhea
What are AE of Bismuth subsalicylate (PeptoBismal)?
darkening of tongue and stools with repeat administration
What is the only FDA recommended OTC absorbent?
Polycarbophil (Fibercon)
What is MOA of Polycarbophil (Fibercon)?
absorbs 60 times its weight in water and can be used to treat both constipation and
diarrhea

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