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Chapter 1: The Foundation of Pharmacology: Quality and Safety
Abrams’ Clinical Drug Therapy: Rationales for Nursing Practice, 13th Edition
1. A woman diagnosed with obsessive–compulsive disorder has been prescribed oralparoxetine hydrochloride.
What is the expected effect for this prescription?
A. Curative effect on symptoms
B. Systemic effect on symptoms
C. Local effect on symptoms
D. Parenteral effect on symptoms
ANS: B
Rationale: Drugs that produce systemic effects are taken into the body, circulated through the
bloodstream to their sites of action in various body tissues, and eventuallyeliminated from the
body. Curative agents are given to cure a disease process. In this case, paroxetine hydrochloride
will control the symptoms but not cure the disorder.
Drugs with local effects, such as sunscreen and local anesthetics, act mainly at the site of application.
Paroxetine hydrochloride is not administered parenterally. Parenteral agents are administered
subcutaneously, intramuscularly, or intravenously.
PTS: 1 REF: p. 3, Introduction OBJ: 1
NAT: Client Needs: Physiological Integrity: Pharmacological and Parenteral Therapies
TOP: Chapter: 1: The Foundation of Pharmacology: Quality and Safety
KEY: Integ Process: Nursing Process
BLM: Cognitive Level: Understand NOT: Multiple Choice
2. A client has been prescribed an antibiotic. This medication is a naturally occurring
substance that has been chemically modified. What is another name for this type of
medication?
A. Synthetic drug
B. Semisynthetic drug
C. Biotechnology drug
D. Prototype drug
ANS: B
Rationale: Semisynthetic drugs (e.g., many antibiotics) are naturally occurring substances that have
been chemically modified. Synthetic drugs are more standardized intheir chemical characteristics,
more consistent in their effects, and less likely to produce allergic reactions. Biotechnology drugs
involve manipulating DNA and RNA and recombining genes into hybrid molecules that can be
inserted into living organisms.
Prototype drugs are the first drug of a particular group to be developed.
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