Test Bank Lilleys Pharmacology For Canadian Health Care Practice 4th Edition Sealock-12-134

Test Bank Lilleys Pharmacology For Canadian Health Care Practice 4th Edition Sealock-12-134

Chapter 05: Gene Therapy and Pharmacogenomics
Sealock: Lilley’s Pharmacology for Canadian Health Care Practice, 4th Edition
MULTIPLE CHOICE
 1. Which is the most important compound that transfers genes from parents to offspring?
a. Chromatin
b. Deoxyribonucleic acid (DNA)
c. Alleles
d. Ribonucleic acid
ANS: B
It is now recognized that DNA is the most important body compound that serves to transfer genes from parents to offspring.
DIF: Cognitive Level: Knowledge
 2. Which is manufactured as a result of indirect gene therapy?
a. Vitamin K
b. epoetin (Eprex)
c. Human insulin
d. Heparin
ANS: C
A recombinant form of human insulin is one of the most widespread uses of indirect gene therapy.
DIF: Cognitive Level: Comprehension
 3. Eugenics is defined as
a. the use of gene therapy to prevent disease.
b. the development of new drugs based on gene therapy.
c. the intentional selection, before birth, of genotypes that are considered more
desirable than others.
d. the determination of genetic factors that influence a person’s response to
medications.
ANS: C
Eugenics is the intentional selection, before birth, of genotypes that are considered more desirable than others. Eugenics is a major
ethical issue related to gene therapy.
DIF: Cognitive Level: Knowledge
 4. What is the main purpose of the Human Genome Project?
a. To study genetic diseases
b. To study genetic traits in humans
c. To discover new genetic diseases
d. To describe the entire genome of a human being
ANS: D
The Human Genome Project was undertaken to describe in detail the entire genome of a human being.
DIF: Cognitive Level: Knowledge
 5. Genotyping for the presence of cytochrome P-450 2D6 (CYP2D6) enzymes and alleles will be helpful in which area of medicine?
a. Cardiology
b. Psychiatry
c. Respirology
d. Oncology
ANS: B
Psychiatry and general medicine will benefit. Genotyping for the presence of CYP2D6 will determine whether patients are poor,
intermediate, extensive, or ultrarapid metabolizers with these enzymes, which will help guide the prescribing of specific
medications.
DIF: Cognitive Level: Comprehension
SHORT ANSWER
 1. Name one clinical application of pharmacogenomics.
ANS:
Several possible clinical applications are listed in Table 5-1: Clinical Applications of Pharmacogenomics.
DIF: Cognitive Level: Application
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Chapter 06: Medication Errors: Preventing and Responding
Sealock: Lilley’s Pharmacology for Canadian Health Care Practice, 4th Edition
MULTIPLE CHOICE
 1. Which situation is an example of a medication error?
a. A patient refuses her morning medications.
b. A patient receives a double dose of a medication because the nurse did not cut the
pill in half.
c. A patient develops hives after starting an intravenous antibiotic 24 hours earlier.
d. A patient reports severe pain still present 60 minutes after a pain medication was
given.
ANS: B
A medication error is defined as a preventable adverse drug event that involves inappropriate medication use by a patient or health
care provider. Refusing morning medications and reporting severe pain after having been given medication are examples of patient
behaviours. The development of hives is a possible allergic reaction. None of these situations is preventable.
DIF: Cognitive Level: Application
 2. Which is the proper notation for the dose of the drug ordered?
a. digoxin .125 mg
b. digoxin .1250 mg
c. digoxin 0.125 mg
d. digoxin 0.1250 mg
ANS: C
Always use a leading zero for decimal dosages (e.g., digoxin 0.125 mg) with medication orders or their transcription. Omitting the
leading zero may cause the order to be misread, resulting in a large drug overdose. Never use trailing zeros.
DIF: Cognitive Level: Application
 3. When the nurse is giving a scheduled morning medication, the patient states, “I haven’t seen that pill before. Are you sure it’s
correct?” The nurse checks the medication administration record and sees that medication is listed. Which is the nurse’s best
response to the patient?
a. “It’s listed here on the medication sheet, so you should take it.”
b. “Go ahead and take it, and then I’ll check with your doctor about it.”
c. “It wouldn’t be listed here if it wasn’t ordered for you!”
d. “I’ll check on the order first, before you take it.”
ANS: D
When giving medications, the nurse must always listen to and honour any concerns or doubts expressed by the patient. If the
patient doubts an order, the nurse should check the written order, check with the prescriber, or both. The other options included
with this example illustrate the nurse’s not listening to the patient’s concerns.
DIF: Cognitive Level: Application
 4. The physician has written admission orders, and the nurse is transcribing them. The nurse is having difficulty transcribing one order
because of the physician’s handwriting. The best action for the nurse to take is to
a. ask a colleague what the order says.
b. contact the physician to clarify the order.
c. contact the pharmacy to clarify the order.
d. ask the patient what medications are being taken at home.
ANS: B
If a prescriber writes an order that is illegible, the nurse should contact the prescriber for clarification. The nurse should not ask a
colleague what the order says because the colleague did not write the order. The nurse should not contact the pharmacy to clarify
the order because this action would delay implementation of the order. Asking the patient what medications are taken at home is
incorrect because this question will not clarify the current order.
DIF: Cognitive Level: Comprehension
 5. Health care providers should report actual and potential medication errors to which organization?
a. Institute for Safe Medications Practices (ISMP) Canada
b. Accreditation Canada
c. Canadian Patient Safety Institute (CPSI)
d. Health Canada
ANS: A
Actual and potential medication errors should be reported to ISMP Canada; confidentiality of the reporter is respected.
Accreditation Canada, CPSI, and Health Canada all offer information pertaining to medication safety.
DIF: Cognitive Level: Knowledge 

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