USMLE GRIND STEP 1 Complete Study Guide Exam Questions (2,000 Terms) with Detailed Definitions 2026-2027 (228pages)

USMLE GRIND STEP 1 often precedes squamous cell carcinoma - Answer: actinic keratosis primary adrenocortical deficiency - Answer: Addison's disease polyostotic fibrous dysplasia, precocious puberty, cafe-au-lait spots, short stature, young girls - diagnosis? - Answer: Albright's syndrome hereditary nephritis with nerve deafness - Answer: Alport's syndrome anti-basement membrane antibodies - diagnosis? - Answer: Goodpasture's syndrome anticentromere antibodies - diagnosis? - Answer: scleroderma (CREST) anti-double-stranded DNA antibodies (ANA antibodies) - diagnosis? - what hypersensitivity type? - Answer: SLE - type III hypersensitivity anti-epithelial cell antibodies - diagnosis? - Answer: pemphigus vulgaris antigliadin antibodies - diagnosis? - Answer: celiac disease antihistone antibodies - diagnosis? - Answer: drug-induced SLE anti-IgG antibodies - diagnosis? - Answer: rheumatoid arthritis antimitochondrial antibodies - diagnosis? - Answer: primary biliary cirrhosis antineutrophil antibodies - diagnosis? - Answer: vasculitis antiplatelet antibodies - diagnosis? - Answer: idiopathic thrombocytopenic purpura USMLE GRIND STEP 1 arachnodactyly - diagnosis? - Answer: Marfan's syndrome Argyll-Robertson pupil - diagnosis? - Answer: neurosyphilis Arnold-Chiari malformation - Answer: cerebellar tonsillar herniation Aschoff bodies - diagnosis? - Answer: rheumatic fever atrophy of the mammillary bodies - diagnosis? - Answer: Wernicke's encephalopathy Auer rods - diagnosis? - Answer: acute myelogenous leukemia (especially promyelocytic type) auto splenectomy - diagnosis? - Answer: sickle cell anemia Babinski's sign is associated with what? - Answer: UMN lesion "Bamboo spine" on x-ray - Answer: ankylosing spondylitis basophilic stippling of RBCs - diagnosis? - Answer: lead poisoning defective dystrophin, less severe than Duchenne's - Answer: Becker's muscular dystrophy LMN CN VII palsy - Answer: Bell's palsy Bence Jones proteins - possible diagnoses? - in each case, what are the proteins? - Answer: multiple myeloma - kappa or lambda light chains Wald Enstrom’s macroglobulinemia - IgM IgA nephropathy - diagnosis? - Answer: Berger's disease USMLE GRIND STEP 1 Bernard-Soulier disease - what is the defect? - Answer: defect in platelet adhesion bilateral hilar adenopathy, uveitis - diagnosis? - Answer: sarcoidosis Birbeck granules on EM - diagnosis? - Answer: histiocytosis X (eosinophilic granuloma) bloody tap on LP - diagnosis? - Answer: subarachnoid hemorrhage "Blue bloater" - Answer: chronic bronchitis blue-domed cysts - diagnosis? - Answer: fibrocystic change of the breast blue sclera - diagnosis? - Answer: osteogenesis imperfecta boot-shaped heart on x-ray - possible diagnoses? - Answer: tetralogy of Fallot or RVH Bouchard's nodes - diagnosis? - where are they located? - why do they occur? - Answer: osteoarthritis - on PIP secondary to osteophytes boutonniere deformity - diagnosis? - Answer: rheumatoid arthritis branching rods in oral infection - diagnosis? - Answer: Actinomyces israelii "Brown tumor" of bone - possible diagnoses? - what causes the brown color? - Answer: hyperparathyroidism or osteitis fibrosa cystica (von Recklinghausen's disease) - color is due to hemorrhage in cysts X-linked agammaglobulinemia - Answer: Bruton's disease