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A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing?
a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs.
b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants.
c. The BRCA2 gene influences metabolism of certain drugs and increases the risk for breast cancer.
d. The x linked OPN1MW gene for male color blindness also slows metabolism of certain - a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs.
HER2 is a gene often implicated with cancer, as is BRCA2. OPN1MW is the gene that codes for color blindness in men. Metabolism of 25% of all prescribed drugs, including tricyclic antidepressants, beta adrenergic receptor blockers, and neuroleptics, is influenced by variants in a certain gene, requiring genetic testing to reduce trial-and-error in estimating appropriate drug-dosage levels.
According to the Centers for Disease Control and Prevention, the 10 most costly chronic conditions include cardiovascular diseases, obesity, asthma, diabetes, smoking and alcohol related conditions, cancer, Alzheimer's disease, arthritis and stroke. Which are the top 4 in ranking from most costly to least costly?
a. Cardiovascular diseases, obesity, diabetes, cancer
b. Cardiovascular diseases, diabetes, obesity, cancer
c. Cardiovascular diseases, Smoking-related conditions, Alcohol-related conditions, diabetes
d. Cardiovascular diseases, Stroke, Obesity, Diabetes - c. Cardiovascular diseases, Smoking-related conditions, Alcohol-related conditions, diabetes
A mother brought her child to the doctor for genetic testing. The health care provider was trying to explain the genetic results of the child. During his explanation he tells the mother that the child has 2 X chromosomes and a Y chromosome in each cell. He begins to explain some physical appearances the mother might notice on her son. He explains that she might notice that he has sparse body hair, long limbs and small testes. The health care practitioner is explaining which syndrome to the mother.
a. Klinefelter syndrome
b. Turners' syndrome
c. Down syndrome
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