3P Gastroenterology - therapy for Helicobacter pylori is: Answer: met...

3P Gastroenterology

• The most commonly reported side effect of metronidazole and clarithromycin combination

therapy for Helicobacter pylori is:

Answer: metallic taste.

2. Infliximab (Remicade), a tumor necrosis factor inhibitor, is:

Answer: used to treatCrohn's disease in children.

3. The plasma elimination half- life of esomeprazole (Nexium) is:

Answer: 1-1.5 hours.

4. The most commonly reported side effects of oral ondansetron (Zofran)are:

Answer: headache and constipation.

5. Metoclopramide (Reglan), an antiemetic, increases gastric motility by:

Answer: -blocking dopamine and serotonin receptors and enhancing the action of acetyl- choline.

• The following medication should NOT be administered concomitantly withclopidogrel

(Plavix):

Answer: omeprazole (Prilosec).

• The first-line regimen for the treatment of Helicobacter pylori is a protonpump inhibitor

(PPI) plus:

Answer: amoxicillin and clarithromycin.

• Which of the following is NOT a 5-HT3 receptor antagonist?

Answer: Prochlorperazine (Compazine)

• Which of the following medications is classified as an antihistamine and aphenothiazine?

Answer: Promethazine (Phenergan)

• Proton pump inhibitors (PPIs), such as pantoprazole (Protonix), block gastrointestinal

acid secretion by:

Answer: inhibiting the hydrogen- potassium ATPasetransport enzyme.

• Promethazine (Phenergan), a 1st generation antihistamine, is contraindicated in the

presence of:

Answer: asthma.

12. Helicobacter pylori is naturally resistant to:

Answer: trimethoprim/sulfamethoxazole(Bactrim). 1 / 2

13. Ondansetron (Zofran) is available as:

Answer: oral elixir, tablets, soluble film, disintegrating tablets, intramuscular and intravenous solution.

• Oral promethazine used for the treatment of nausea and vomiting shouldbe administered

as needed every:

Answer: 4 hours.

• Prior to the initiation of long- term treatment with a proton pump inhibitor(PPI) and

periodically during therapy, the nurse practitioner should monitor serum:

Answer: magnesium.

• Histamine receptor antagonists (H2RA), such as famotidine (Pepcid), inhibit acid

secretions by:

Answer: blocking the parietal cells (acid- producers) from responding to histamine.

• The class of medications most useful in the treatment of chemotherapyinduced nausea

and vomiting is the:

Answer: serotonin receptor antagonists.

• The recommended duration of therapy for eradication of Helicobacterpylori is:

Answer: 14 days.

• Corticosteroids, used in the treatment of ulcerative colitis, usually doNOT:

Answer: increase the effectiveness of antibiotics.

• A patient who has failed two courses of therapy for Helicobacter pylorishould:

Answer: receive reinforced education about compliance with medications.

21. The brand name of pantoprazole is:

Answer: Protonix.

• Pantoprazole, a proton pump inhibitor, given with antibiotics for triple therapy treatment

of Helicobacter pylori should be administered:

Answer: twice daily.

23. The antiemetic that does NOT have potential to cause QT prolongationis:

Answer: promethazine (Phenergan).

24. Ondansetron (Zofran) dosage should be adjusted in patients:

Answer: with hepaticimpairment.

• In the patient with an allergy to penicillin, treatment of Helicobacter pyloriwould include

a proton pump inhibitor plus:

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