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APhA immunization certification 1.Main WBC of innate immunity
- process?: Macrophages
-engulf antigens, deliver to T-cells which release cytokines
2.WBC of cellular immunity: T-cells
-helper T: attach antigen, release cytokines, generate B-cell response
-cytotoxic T cells: destroy antigens
3.WBC of humoral immunity: B-cells
-mature to plasma cells (secrete antibodies) -some remain as memory cells
4.Consideration for live attenuated vaccines: Must replicate to work
5.Consideration for inactivated vaccines: Antigen load stimulates
immune re- sponse
6.Polysaccharide vs conjugate polysaccharide vaccines?: Polysaccharide
-do not stimulate t-cells, short-lived immunity, no boost Conjugate polysaccharide -stimulate t-cells, there for memory/boost
7.Vaccination important during pregnancy: Tdap for *every* pregnancy
after 20 weeks gestation (inactivated flu vaccine as well) 1 / 2
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8.General consideration for immunosuppression and timeline of vaccine administration: live vaccines: 4 weeks before
inactivated vaccines: 2 (4) weeks before
9.Shift vs drift
- new vaccine each year due to: Shift = large change in type
A flu drift = small change in type A/B flu
- *DRIFT*
10.Age recommendation for flu vaccination: over 6 mo, no
contraindications = GIVE if 6mo-8 years and never had, 2 DOSES *FOUR WEEKS* APART
11.Egg allergy concern for: Flu vaccine - hives
*give anyway* 12.Timeline for PPSV23 and PCV13 for 65+ -vaccine naive
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