Course: Advanced Pharmacology

Chamberlain University

NR 546 / NR546

Week 8 Neurotransmitter Table

Course: Advanced Pharmacology

• / 2

Carolyne Nchabera Neurotransmitter Table

• To be completed throughout course and submitted in Week

8* Neuro transmitter Receptor Subtype Location/Function/E�ects /symptoms of excess or de�cit if applicable Distribution

(ie:

CNS/PNS,

GI, vascular) Drug classes that target this neurotransmitter or receptor Speci�c medications that target this neurotransmitter or receptor Glutamate AMPA Ligand-gated ion channels Modulates cell excitability by allowing the �ow of calcium and sodium ions into the cell.Located at the CNS in neurons and glia.Excess has resulted in schizophrenia, epilepsy, and mania.

CNS NMDA glutamate antagonist Barbiturates Antiepileptics Memantine PCP Ketamine Dextromethorphan Dextromethadone Parampanel NMDA Ligand-gated ion channels, strengthens synapses and is involved in strong memory formation.Excess is associated with memory and learning impairments, psychosis, and excitotoxic brain injury.

CNS NMDA receptor antagonist Antipsychotics Loop Diuretics Opiates Antidepressants Memantine Amantadine Ketamine Dextromethorphan Methadone Dextropropoxyphene Ketobemidone Furosemide Haldol Tramadol GABA GABA a Ligand-gated ion channels Functions as postsynaptic inhibition by CI-in�ux Inotropic receptor Reduces fear, anxiety, and CNS Limbic system Striatum Medulla Spinal Cord Benzodiazepines Hypnotics Neuroactive steroids Lorazepam, Clonazepam, Alprazolam Zolpidem, Zopiclone, zaleplon Allopregnanolone Downloaded by Benjamin Luca ([email protected]) lOMoARcPSD|51648332

• / 2