Final Exam: NR 546 NR546 Latest

Final Exam: NR 546 / NR546 (Latest

Update 2025 / 2026) Advanced

Pharmacology: Psychopharmacology

for the Psychiatric-Mental Health Nurse Practitioner | Questions & Verified Answers | 100% Correct | Grade A - Chamberlain

Question:

pharmacologic treatment for bipolar disorder

Answer:

lithium, anticonvulsants, second gen antipsychotics

Question:

lithium

Answer:

used for euphoric mania, rapid cycling, or maintenance therapy

MOA: alters cation transport in the nerve and muscle

*1st line of treatment for new onset bipolar with acute mania 1 / 4

Question:

lithium labs

Answer:

serum thyroid level, renal function, thyroid function

• can cause renal and thyroid tox

-monitor lithium levels 5 days after any dose adjustment -monitor lithium levels regularly q6mo starting dose should be decreased by 50% for pts with renal failure -avoid in pregnancy and breast feeding

Question:

lamotrigine

Answer:

maintenance therapy or monotherapy for bipolar

MOA: affects sodium ion transport and enhances the activity of y-

aminobutyric acid (GABA)

• well tolerated but can cause a rash
• avoid in breast feeding

• / 4

Question:

valproic acid

Answer:

used for acute mania, mixed mood, multiple prior episodes, comorbid substance abuse

MOA: affects ion transport and enhances the activity of GABA

-teratogenic avoid in pregnancy

Question:

valproic acid labs

Answer:

serum valproate level, liver fxn, cbc -can cause thrombocytopenia, leukopenia, hepatotoxicity -monitor labs q 3 mo for 1 yr ,then annually

• / 4

Question:

SGAs

Answer:

used in acute bipolar depression, acute mania or mixed episodes, or as bipolar maintenance/adjunct

MOA: DA, NE, 5HT receptor antagonists

labs: cbc, HgB A1C

-can increase bs and cause DMII, blood dyscrasias -labs q 3 mo for 1 yr, then annually

Question:

SGA drugs

Answer:

aripiprazole cariprazine lurasidone (take with food, safe for preg) quetiapine asenapine risperidone olanzapine ziprazadone

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