Final Exam Review: NR565 NR 565

Final Exam Review: NR565 / NR 565

(Latest Update 2025 / 2026) Advanced Pharmacology Fundamentals | Questions and Answers | Grade A | 100% Correct – Chamberlain

Question:

GERD: PPI mechanism of actions

Answer:

inhibits H+,K+-ATPase (proton pump) that generates gastric acid

Question:

GERD: discontinuation of PPI

Answer:

-should be limited to 4-8 weeks but relapse symptoms typically occur within

• to 12 months

-with severe GERD, long-term therapy is recommended

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Question:

GERD: PPI adverse effects

Answer:

fracture, pneumonia, acid rebound, C. diff

Question:

GERD: PPI therapeutic use

Answer:

suppress gastric acid secretion

Question:

GERD: therapeutic use of omeprazole

Answer:

short-term therapy of ulcers, erosive esophagitis, and GERD long-term use for hypersecretory states

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Question:

GERD: sucralfate drug interactions

Answer:

-can impede absorption of phenytoin, theophylline, digoxin, warfarin, and fluoroquinolone antibiotics -administer at least 2 hours from other drugs

Question:

GERD: sucralfate mechanism of action

Answer:

under mildly acidic conditions, sucralfate undergoes polymerization resulting in a viscid and very sticky gel that adheres to the ulcer crater, creating a barrier

Question:

PUD: H. pylori treatments

Answer:

combo of clarithromycin, amox, bismuth, metronidazole, and a tetracycline plus a PPI

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Question:

PUD: antacid adverse effects

Answer:

constipation and diarrhea, sodium loading leading to HTN or HF exacerbation

Question:

PUD: cimetidine adverse effects

Answer:

antiandrogenic effects, CNS effects (hallucinations, confusion or depression/excitation), pneumonia

Question:

PUD: cimetidine mechanism of action

Answer:

selectively blocks H2 receptors to decrease gastric acid secretion

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