HESI Pharmacology Exam Practice

HESI Pharmacology Exam Practice (NCLEX-PN) | 2025/2026 Latest Edition – Version 1 Real Exam-Based Questions and Verified Rationalized Answers | 100% Accuracy | Practical Nursing Pharmacology | Graded A+ Introduction This resource includes two full versions of the HESI Pharmacology Practice Exam tailored for the NCLEX-PN® 2025/2026 cycle. Each version contains 75+ multiple-choice questions covering medication classifications, dosage calculations, side effects, contraindications, and nursing implications. Content is aligned with current pharmacological standards and NCLEX-PN® blueprint requirements.Answer Format All correct answers are clearly marked in bold and green, each supported by concise rationales for improved clinical understanding and retention.

Version 1: Questions (1–75)

• A client is prescribed 500 mg of amoxicillin PO every 8 hours. The

capsules available are 250 mg each. How many capsules should the nurse administer per dose?

• 1 capsule
• 2 capsules
• 3 capsules
• 4 capsules
• 2 capsules

Rationale: 500 mg ÷ 250 mg/capsule = 2 capsules per dose.

• A nurse is preparing to administer heparin 5,000 units

subcutaneously. Which site is most appropriate for this injection?

a) Deltoid muscle

b) Anterior thigh 1 / 3

c) Abdomen

d) Upper arm

c) Abdomen

Rationale: The abdomen is the preferred site for subcutaneous heparin to minimize bruising and ensure absorption.

• A client with type 2 diabetes is prescribed metformin. Which side

effect should the nurse teach the client to monitor for?

a) Weight gain

b) Gastrointestinal upset

c) Hypertension

d) Hypokalemia

b) Gastrointestinal upset

Rationale: Metformin commonly causes gastrointestinal side effects, such as nausea and diarrhea.

• A client is to receive 0.5 mg of lorazepam IV. The vial contains 2

mg/mL. How many mL should the nurse administer?

• 0.25 mL
• 0.5 mL
• 1 mL
• 1.5 mL
• 0.25 mL

Rationale: 0.5 mg ÷ 2 mg/mL = 0.25 mL.

• A client is prescribed furosemide for heart failure. Which electrolyte

imbalance should the nurse monitor for?

a) Hyperkalemia

b) Hypokalemia

c) Hypernatremia

d) Hyponatremia

b) Hypokalemia

Rationale: Furosemide, a loop diuretic, increases potassium excretion, leading to a risk of hypokalemia. 2 / 3

• A nurse is administering insulin glargine to a client with diabetes.

When is the best time to administer this medication?

a) Immediately before meals

b) At bedtime

c) Every 4 hours

d) With breakfast

b) At bedtime

Rationale: Insulin glargine is a long-acting insulin typically administered at bedtime to provide basal coverage.

• A client is prescribed 20 mg of prednisone PO daily. The tablets are 10

mg each. How many tablets should the nurse administer?

• 1 tablet
• 2 tablets
• 3 tablets
• 4 tablets
• 2 tablets

Rationale: 20 mg ÷ 10 mg/tablet = 2 tablets.

• A client with a history of asthma is prescribed albuterol via inhaler.

What is the primary purpose of this medication?

a) Reduce inflammation

b) Prevent infection

c) Relieve bronchospasm

d) Control blood pressure

c) Relieve bronchospasm

Rationale: Albuterol, a beta-2 agonist, relaxes bronchial smooth muscle to relieve bronchospasm in asthma.

• A client is to receive 1000 mL of normal saline over 8 hours. What is

the IV flow rate in mL/hr?

• 100 mL/hr
• 125 mL/hr
• 150 mL/hr
• 175 mL/hr
• / 3