.png){kind=logo}
BIOD351 / BIOD 351 Module 8 (Latest Update 2025 / 2026) Pharmacology | Questions & Answers | Grade A | 100% Correct - Portage Learning
Question:
What are tricyclic antidepressants?
Answer:
They are named for their three ringed structure and they work by correcting the imbalance of serotonin and norepinephrine in the nerve endings of the CNS. It is blocking the reuptake of those neurotransmitters from going back into the adrenergic receptors. It used for neuropathic pain.
Question:
What is the tricyclic Clomipramine used for?
Answer:
OCD
- / 4
Question:
What is the tricyclic antidepressant, Imipramine used for?
Answer:
Imipramine is used for bedwetting in children.
Question:
What the adverse events associated with tricyclic antidepressants?
Answer:
Anticholinergic: Urinary retention, constipation
Adrenergic and Dopaminergic blockade: cardiac side effects.
Histamine blockade: sedation
Serotonin blockade: lower seizure threshold, sexual dysfunction
Question:
What are the drug interactions associated with tricyclic antidepressants?
Answer:
Not be combined with MAOIs due to increased risk of serotonin syndrome.
- / 4
Question:
What are monoamine oxidase inhibitors and how do they work?
Answer:
They are rarely used for depression because of the adverse effects and serotonin syndrome risk. They inhibit monoamine oxidase, an enzyme that breaks down neurotransmitters. It is used for Parkinson's disease.
Question:
What are the adverse effects associated with MAOIs?
Answer:
Anticholinergic, hypotension, weight gain, sexual dysfunction. CNS
disturbances: restlessness dizziness, insomnia, tremors, seizures
Question:
How do SSRIs and SNRIs work?
Answer:
First introduced in the 1980's with Fluoxetine (Prozac), SSRIs block the reuptake of serotonin and SNRIs block the reuptake of both serotonin and norepinephrine. It is used for primary depression, bipolar, eating disorders, and panic attacks/ social anxiety.
- / 4
Question:
Why cant SSRIs be used as monotherapy for bipolar disorder?
Answer:
They can swing people into manic episodes with the lack of depressing chemicals.
Question:
What are the adverse events and drug interactions associated with SSRIs an SNRIs?
Answer:
Insomnia, weight gain, sexual dysfunction. They can also cause serotonin syndrome when combined with other drugs that increase serotonin levels.Other interactions include increased potential for Benzo toxicity, increased warfarin and phenytoin (antiepileptic) levels. Migraine medications may also increase bleeding risk when on NSAIDs or warfarin.
Question:
What are the symptoms of serotonin syndrome?
Answer:
Confusion, rapid heart rate, sweating, headache, muscle rigidity, fever, and in severe cases seizures, irregular heartbeat, and unconsciousness.
- / 4
.png)