Midterm Exam: NR 565 NR565

Midterm Exam: NR 565 / NR565

(Latest Update 2025 / 2026) Advanced Pharmacology Fundamentals | Questions & Answers | Grade A | 100% Correct – Chamberlain

Question:

Opioid Abuse Screening Tool

Answer:

NIDA-Modified ASSIST

Question:

NSAIDs MOA

Answer:

Inhibition of COX-1: protection against MI and stroke; gastric erosion and

ulceration, bleeding tendencies, renal impairment

Inhibition of COX-2: suppression of inflammation, alleviation of pain,

reduction of fever, protection against colorectal cancer; renal impairment, promotion of MI and stroke secondary to suppressing vasodilation 1 / 4

Question:

NSAIDs Adverse Effects

Answer:

Gastric ulceration, bleeding renal impairment MI, stroke (NOT aspirin)

Question:

Aspirin

Answer:

Nonselective inhibitor of cyclooxygenase Reductions of inflammation, pain, and fever- result from inhibiting COX-2 Can protect against MI and stroke

Question:

Nonacetylated Salicylates

Answer:

Magnesium salicylate, sodium salicylate, salsalate

Inhibit COX-1 and COX-2 Used to treat arthritis, moderate pain, fever Most common adverse effects are GI disturbances 2 / 4

Question:

Nonacetylated Salicylates Contraindications

Answer:

Sodium salicylate should be avoided in patients on sodium-restricted diet (HTN, heart failure) Magnesium salicylate may accumulate to toxic levels in patients with chronic renal insufficiency Should not be given to children with chickenpox or influenza due to possibility of precipitating Reye syndrome

Question:

Ibuprofen

Answer:

Inhibits cyclooxygenase and has anti inflammatory, analgesic, and antipyretic actions Used to treat fever, mild to moderate pain, and arthritis Superior for dysmenorrhea; good inhibition of cyclooxygenase in uterine smooth muscle

Rare hypersensitivity reaction is Stevens-Johnson syndrome

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Question:

Celecoxib MOA

Answer:

Selective inhibition of COX-2, the COX isoform whose products mediate inflammation and pain At therapeutic doses, celecoxib does not inhibit COX-1, the COX isoform whose products protect the stomach, help maintain renal function, and promote platelet aggregation

Question:

NSAID Use in Rheumatoid Arthritis

Answer:

Provide rapid relief of symptoms but do not prevent joint damage and do not slow disease progression Safer than DMARDs and glucocorticoids; require less vigorous monitoring All NSAIDs have essentially equal antirheumatic effects; may be necessary to try more than one as people will respond differently

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