NAPLEX Actual Exam 100 Verified

NAPLEX Actual Exam / | 100 Verified Questions & Correct Answers | Already Graded A+​ North American Pharmacist Licensure Examination (NAPLEX) | Pharmacotherapy, Clinical Calculations, Patient Safety, Medication Therapy Management, and Regulatory Standards | Expert-Verified Q&A | Certification-Ready

Introduction​ This document provides the complete and updated NAPLEX Actual Exam for the / cycle. It includes 100 multiple-choice questions covering critical domains: pharmacokinetics, clinical pharmacology, patient assessment, pharmaceutical calculations, medication safety, medication therapy management, and regulatory standards. Aligned with the National Association of Boards of Pharmacy (NABP) competency statements and current clinical guidelines (e.g., ACC/AHA, ADA, FDA regulations), all answers are expert-verified, graded A+, and designed to ensure success in achieving pharmacist licensure and excellence in clinical practice.Answer Format​ Correct answers are highlighted in bold and green, with detailed rationales explaining the clinical reasoning, referencing current guidelines and standards to reinforce mastery of pharmacy knowledge for safe and effective practice.NAPLEX Exam / | Verified Questions & Correct Answers | 100% Success Guarantee | Already Graded A+

NAPLEX Actual Exam Questions (1–100)

• What is the first-line treatment for a patient with newly diagnosed type 2

diabetes mellitus?​

a) Insulin glargine​

b) Metformin​

c) Glipizide​

d) Pioglitazone​

b) Metformin​

Rationale: Metformin is the first-line treatment for type 2 diabetes mellitus due to its efficacy, safety profile, and ability to reduce hepatic glucose production, per ADA guidelines.

• A patient is prescribed warfarin 5 mg daily. What is the target INR for

atrial fibrillation?​

• 1.5–2.0​ 1 / 3

• 2.0–3.0​
• 3.0–4.0​
• 4.0–5.0​
• 2.0–3.0​

Rationale: The therapeutic INR range for warfarin in atrial fibrillation is 2.0–3.0 to balance anticoagulation and bleeding risk, per ACC/AHA guidelines.

• Calculate the creatinine clearance for a 70-year-old male patient

weighing 70 kg with a serum creatinine of 1.2 mg/dL.​

• 45 mL/min​
• 55 mL/min​
• 65 mL/min​
• 75 mL/min​
• 55 mL/min​

Rationale: Using the Cockcroft-Gault formula: CrCl = [(140 – age) × weight (kg)] / (72 × SCr), CrCl = [(140 – 70) × 70] / (72 × 1.2) ≈ 55 mL/min, adjusted for male gender.

• What is the most common side effect of lisinopril?​

a) Hyperkalemia​

b) Dry cough​

c) Hypoglycemia​

d) Bradycardia​

b) Dry cough​

Rationale: Lisinopril, an ACE inhibitor, commonly causes a dry cough due to bradykinin accumulation, per clinical pharmacology.

• A patient is allergic to penicillin. Which antibiotic is a safe alternative for

treating a streptococcal infection?​

a) Amoxicillin​

b) Azithromycin​

c) Cefazolin​

d) Piperacillin​

b) Azithromycin​

Rationale: Azithromycin, a macrolide, is a safe alternative for penicillin-allergic patients, as it has no cross-reactivity, per IDSA guidelines.

• What is the maximum daily dose of acetaminophen for an adult with no

hepatic impairment?​

• 2,000 mg​
• 3,000 mg​
• 4,000 mg​
• 5,000 mg​
• 4,000 mg​

Rationale: The maximum daily dose of acetaminophen for adults is 4,000 mg to prevent hepatotoxicity, per FDA guidelines. 2 / 3

• A patient is prescribed atorvastatin 40 mg daily. What is the primary

indication?​

a) Hypertension​

b) Hyperlipidemia​

c) Heart failure​

d) Type 2 diabetes​

b) Hyperlipidemia​

Rationale: Atorvastatin, a statin, is primarily indicated for hyperlipidemia to reduce LDL cholesterol, per ACC/AHA guidelines.

• What is the antidote for heparin overdose?​

a) Vitamin K​

b) Protamine sulfate​

c) Flumazenil​

d) Naloxone​

b) Protamine sulfate​

Rationale: Protamine sulfate reverses heparin’s anticoagulant effects by binding to it, per clinical pharmacology.

• A patient with asthma is prescribed albuterol. What is its mechanism of

action?​

a) Anticholinergic​

b) Beta-2 agonist​

c) Corticosteroid​

d) Leukotriene modifier​

b) Beta-2 agonist​

Rationale: Albuterol stimulates beta-2 receptors, causing bronchodilation in asthma, per GINA guidelines.

10. A prescription reads: “Amoxicillin 500 mg PO TID for 10 days.” How

many capsules are needed?​

• 20 capsules​
• 30 capsules​
• 40 capsules​
• 50 capsules​
• 30 capsules​

Rationale: TID (three times daily) for 10 days = 3 capsules/day × 10 days = 30 capsules.

• What is the black box warning for fluoroquinolones?​

a) Hepatotoxicity​

b) Tendon rupture​

c) Nephrotoxicity​

d) Cardiotoxicity​

b) Tendon rupture​

• / 3